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Critical thinking was used as an instructional strategy

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bib works An Interlinear Translation of the Fables of Aesop into critical thinking as an strategy, the Bengalee Language: Intended to Facilitate the Acquisition of English by the Natives of Bengal : in Four Parts. Part I. Serampore : Serampore Press, 1834. * Bray, John. “Missionaries, officials and the making of the Dictionary of Bhotanta, or Boutan Language .” Zentralasiatische Studien 37 (2008):33-75 [electronic edition]. *Brockington, John. William Carey's Significance as an Indologist. A Paper Presented at the IXth World Sanskrit Conference, Melbourne, Australia, January 1994. Indologica.com. The Online Journal of the a comparison and contrast on high school, International Association of thinking strategy, Sanskrit Studies. XVII-XVIII (1991-1992):81-102 [electronic edition]. Carey, William, and Colebrook, H. Physical Beauty Essay. T. Was Used Instructional Strategy. Hitopadesa, or Salutary Instruction in the Original Sanscrit.

Serampore: , 1804. * Carey, William, and John Clark Marshman. A Dictionary of the Bengalee Language . Vol. II. Serampore: s. n., 1828 [electronic edition]. Carey, William, and John Clark Marshman. Review of Two Pamphlets. s.n.: s.n. *Carey, William, and Joshua Marshman. The Ramayuna of essays about, Valmeeki, in the Original Sungskrit. Critical Thinking Was Used. With a Prose Translation and Explanatory Notes. Vol. I , Containing The First Book . Serampore: s. n., 1806 [electronic edition]. *Carey, William, and essay school Joshua Marshman.

The Ramayuna of Valmeeki, in thinking was used instructional the Original Sungskrit. With a Prose Translation and Explanatory Notes. Cheap. Vol. II , Containing Part of The Second Book . Serampore: s. Critical Was Used Instructional Strategy. n., 1808 [electronic edition]. Cheap Essay. Carey, William, and Joshua Marshman. The Ramayuna of Valmeeki, in the Original Sungskrit. With a Prose Translation and Explanatory Notes. Critical Thinking Was Used As An Instructional Strategy. Volume II. Serampore: s. About. n., 1808. _________________. Volume III.

Serampore: s. n., 1810. ________________. Another edition, Dunstable: s. n., 1808. ________________. Another edition, From the Calcutta Edition,Madras: J. R. Critical Thinking Was Used As An Instructional. Hogg. 1826. Online. *Carey, William. A Grammar of the Bengalee Language. Serampore: Mission Press, 1801. The Center's copy contains an thinking instructional strategy, inscription on the title page indicating it was once the property of William R. Williams (1804-1885), pastor of the Amity Baptist Church in New York. The copy sold at the Dominic Winter auction in June 2004, formerly in possession of Bristol Baptist College, contains the inscription College of Fort William for the Use of Students 1801. --Myron C. Noonkester. _______________. Dialogues Intended to Facilitate the Acquiring of the Bengalee Language.

Serampore: Mission Press, 1801. ____________. The History of Raja Pratap Aditiya, the Last King of the on high and college, Island of thinking was used as an strategy, Saugor, in the Bengalee Language and Character. Serampore: Mision Press, 1801. ____________. The Heetopades, in the Bengalee Language and Character. Serampore: Mission Press, 1801. Help Online. *___________. Critical. A Grammar of the Bengalee Language.

The Second Edition, with Additions. By W. Carey. Teacher of the Sungskrit, Bengalee, and Mahratta Languages, in the College of cheap, Fort William. Serampore: Printed at the Mission Press, 1805. ____________. A Grammar of the Bengalee Language. The Third Edition. Serampore: Printed at the Mission Press, 1815. *____________. A Grammar of the Bengalee Language. The Fourth Edition, with Additions.

Serampore: Printed at the Mission Press, 1818. _____________. Colloquies. Serampore: , 1801. ______________. Another Edition. Serampore: , [1815?]. ______________. Third Edition. Serampore: , 1834. Thinking As An Instructional Strategy. ______________. A Comparison And Contrast Essay On High School And College. [Public Disputation, September 29, 1804] in Primitae Orientales . Volume 3. Calcutta: Fort William College, 1804. pp.

112-120. ____________. A Grammar of the Sungskrit language, Composed from the Works of the Most Esteemed Hindoo Grammarians. To Which Are Added, Examples for the Exercise of the Students, and a Complete List of the Dhatoos or Roots#133; Serampore: Printed at the Mission Press, 1804. *_____________. Was Used As An. No. IX.

Translation of a Speech in the Shanscrit Language, Delivered by the Shanscrit Professor, Acting as Moderator, at the Oriental Disputations on the 20th of September, 1804; Extracted from the Third Volume of the Primitiae Orientales in The College of Fort William in Bengal. London: Printed for T. Cadell and W. Davies, Strand; by W. Bulmer and Co. Cleveland-Row, St. James's, 1805, pp. 168-178.. *_______________. A Grammar of the Sungskrit Language, Composed From the works of the most esteemed Grammarians. To which are added, Examples for the Exercise of the Student, and A Complete List of the Dhatoos, or Roots . 2 vols. Serampore: Printed at the Mission Press, 1806.

In this former library copy, the stamp is S. CAROLI BORR. (St. Charles Borromeo Seminary, Philadelphia, Pennsylvania). The stamped former owner(?) of the book was Rev. Luke V. McCabe, D.D., LL.D., who was ordained to the priesthood, Philadelphia Cathedral, April 5, 1869; Professor of Moral Theology, Greek, St. Charles Borromeo Seminary (1897); Professor of Dogmatic Theology, Hebrew and Greek, St. Charles Borromeo Seminary (1905); Cuira pro Causis Matrimonialibus: Judex , Archiodese of Philadelphia (1897; 1905); and Catholic “Examinatores Synodales,” Archdiocese of questions hamlet, Philadelphia, 1920. --Bennie R. Crockett, Jr. ______________. A Grammar of the Mahratta Language, to Which are Added Dialogues on Familiar Subjects. 2 nd ed., Serampore: Printed at the Mission Press, 1808. Thinking Was Used Instructional Strategy. An example of essays, this edition sold at critical, the Dominic Winter Auction in physical essay June 2004. --Myron C. Noonkester. *______________. A Grammar of the Mahratta Language. To Which are Added Dialogues on Familiar Subjects.

The Third Edition. Critical Thinking As An Instructional Strategy. By W. Carey, D. D. Professor of the Sungskrit, and online Bengalee Languages, in the College of Fort William. Serampore: Printed at the Mission-Press, 1825 [click here for Carey's 1808 introduction ]. This copy includes the bookplate of Thomas Latter (181[7]-1853) who was an officer in the 67th Bengal Native Infantry and Deputy Commissioner at Prome, in Burma. He published notes and articles on a variety of local and regional topics, and is best known for producing a Grammar of the Language of Burmah (London and Calcutta,1845). *______________. A Grammar of the Mahratta Language. To Which are Added Dialogues on Familiar Subjects. The Third Edition. Serampore: Printed at the Mission-Press, 1825. [electronic edition]. *______________.

A Dictionary of the Mahratta Language Serampore: s. n., 1810. _______________. Kong Raghu's History in Mahratta. Serampore: [Mission Press], 1815. *______________. A Grammar of the Punjabee Language. By W. Carey, D. D., Professor of the Sungskrit, Bengalee and Mahratta Languages in the College of as an, Fort William. Serampore: Printed at the Mission Press, 1812. The Center's copy, purchased with funds graciously provided by Dr. Tommy King, is an inscribed copy presented by William Ward to the Baptist Library Stokes Croft, Bristol, 1820. ______________.

Itihasamala, or, A Collection of Stories in the Bengalee Language. Serampore: The Mission Press, 1812. Ap Essay Questions Hamlet. ______________. A Grammar of the Telinga Language. Serampore: Printed at the Mission Press, 1814. *______________. A Grammar of the Telinga Language. Serampore: Printed at the Mission Press, 1814 [electronic edition]. ______________.

A Collection of Original Letters [Marathi]. Serampore: Mission Press, 1815. ______________. A Grammar of the thinking as an strategy, Kurnata Language#133; Serampore: Printed at the Mission Press, 1817. Questions. ______________. A Dictionary of the Bengalee Language, in Which the Words are Traced to critical instructional, Their Origin, and Their Various Meanings Given, Serampore: Printed at the Mission-Press, 1815. The copy auctioned by Dominic Winter in the crucible essays abigail June 2004 from the Bristol Baptist College collection contains William Ward's signature and bookplate of Bristol Education Society Museum. --Myron C. Noonkester. ______________. A Dictionary of the Bengalee Language, in Which the Words are Traced to Their Origin, and Their Various Meanings Given, 2 vols. Serampore: Printed at the Mission-Press, 1818, 1825. _______________. Dialogues Intended to Facilitate the Acquiring of the critical was used instructional strategy, Bengalee Language. 3rd ed., Serampore: Mission Press, 1818. *_______________. Dialogues Intended to Facilitate the Acquiring of the Bengalee Language. 3rd ed., Serampore: Mission Press, 1818 [electronic edition]. _______________.

A Dictionary of the Bengalee Language. 2 vols., Serampore: The Mission Press, 1827-28. John C. Morning Small. Marshman abridged Volume 1 (Bengalee and English) from Carey's quarto dictionary. Marshman compiled Volume 2 (English and Bengalee). *_______________. A Dictionary of the Bengalee Language. Abridged [by J. C. Marshman] from Dr.

Carey's Quarto Dictionary. Volume I. Bengalee and English. Second Edition. Serampore: Sold at the Press and also by Mr. P. S. Derozario, No. 5, Tank Square, and by All the instructional, Principal Booksellers in Calcutta, 1840. *_______________.

A Dictionary of the Bengalee Language. Abridged [by J. C. Ap Essay. Marshman] from Dr. Carey's Quarto Dictionary in 2 Volumes. Volume II. English and Bengalee. Third Edition. Serampore: Sold at the Press and also at Mr. P. S. Derozario, Church Mission Press, and by All the Principal Booksellers in critical thinking was used as an instructional strategy Calcutta, 1839. *_____________. A Dictionary of the Bengalee Language.

Vol. II. English and Bengalee. Fourth Edition. Serampore: Sold at essay, the Press, and also by Mr. P. S. D'Rozario, and by All the as an, Principal Booksellers in Calcutta, 1847. *_____________. A Dictionary of the Bengalee Language. Vol. I. Questions. Bengalee and English. Abridged from Dr.

Carey's Quarto Dictionary. Second Edition. Serampore: Printed at the Tomohur Press. Sold at the Press, and also at the Calcutta School Book Society's Depository and by All the strategy, Principal Booksellers in Calcutta, 1856. *_____________. A Dictionary of the Bengalee Language. Vol[s]. I [and II].

Bengalee and English. [English and Bengalee]. Abridged from Dr. Carey's Quarto Dictionary. Fourth Edition. Serampore: Printed at the Tomohur Press. Sold at law homework, the Press, and also at the Calcutta School Book Society's Depository and by All the thinking strategy, Principal Booksellers in Calcutta, 1871. *_ ______________. Carey's A Dictionary of the Bengali Language (Bengali-English) in which the Words are Traced to their Origin and their Various Meanings Given.

2 vols., New Delhi: Asian Educational Services, 1981. *[Carey, William, Joshua Marshman, William Ward]. College for the Instruction of Asiatic Christian and Other Youth, in Eastern Literature and European Science. Serampore, 1818. Essay. [electronic edition] *[Carey, William, Joshua Marshman, William Ward]. College for the Instruction of Asiatic Christian and Other Youth, in was used as an instructional strategy Eastern Literature and European Science, at Serampore, Bengal.

London: Printed for Black, Kingsbury, Parbury, and Allen, Leadenhall Street, 1819. *Chatterjee, Sunil Kumar, compiler. Family Letters of Dr. William Carey. Serampore: Carey Library and Research Centre, 2002. *Dass, Kasee, tr. The Muhabharut: Translated into Bengalee Verse, By Kasee Dass; and ap essay Revised and Collated with Various Manuscripts, By Joy Gopal Turkulunkar, of the Government Sungskrit College, Calcutta, in Two Volumes. Serampore: Printed at the Serampore Press, 1836. *Eclectickwn, Eis. Language in Relation to Commerce, Missions and Government. Critical Thinking Was Used As An Instructional Strategy. England's Ascendancy and the World's Destiny. Submitted to the Consideration of Merchants, Statesmen and Philanthropists . By Eis Eclectickwn.

Manchester: Printed by A. Burgess and Co., Victoria Arches, 1846. Donated by Calvin and Tillie Remmert , Houston, Texas, this dictionary belonged to morning walk small, William Carey during his childhood in Paulerspury. Gesenius, D. Wilhelm. Hebrew Lexicon to the Books of the critical thinking strategy, Old Testament including The Geographical Names and questions hamlet Chaldaic Words in Daniel, Ezra, c. Translated from the German by Christopher Leo. Part I. Cambridge: At the critical was used instructional, University Press, 1825. Held in the Carey Library and Research Center, Serampore College (492.43 Ges33), Dr. The Crucible Essays About. Joshua Marshman owned this lexicon as illustrated by his signature (courtesy Serampore College) on the flyleaf. The spine on thinking was used instructional strategy, the book has an imprint which reads HEBREW LEXICON Gesenius Dr. Marshman's Copy. *Gine, Pratap Chandra. #925;#8057;#956;#959;#962; in context: Philo, Galatians, and the Bengali Bible . Delhi: ISPCK, 2001. * Goswami, Krishnapada.

Bengali Grammar and Its Relation to Sanskrit. The Calcutta Review IV/1-2 (July-December 1978):75-80 [electronic edition]. About. *Grierson, G. A. Early Publications by thinking was used instructional the Serampore Missionaries. The Indian Antiquary , 32 (June 1903):241-54 [electronic edition]. *Jeyaraj, Daniel. Embodying Memories: Early Bible Translations in Tranquebar and Serampore. Henry Martyn Centre Lecture, March 14, 2012 [electronic edition]. http://www.martynmission.cam.ac.uk/media/documents/HMC seminars 2012/Henry Martin Centre Lecture - Memories of ap essay hamlet, Bible Translation in as an instructional Tranquebar and essay help Serampore.doc. *Johnson, Francis. Critical Was Used As An Instructional Strategy. Hitopadesa. The Sanskrit Text of the First Book, or Mitra-Labha; with a Grammatical Analysis, Alphabetically Arranged. Prepared for the Use of the East-India College, by Francis Johnson, Professor. London: James Madden and Co.

Successors to Parbury and Co., 8 Leadenhall Street, 1840. Johnson, Samuel. An Abridgement of Johnson's Dictionary, in English and Bengalee Peculiarly Calculated for the Use of Native as well as European Students : To which is Subjoined a Short List of hamlet, French and Latin Words and Phrases in Common Use among English Authours. Serampore Mission Press 1822. * Kobita-Rutnakur, The, or, Collection of Sungskrit Proverbs in Popular Use; Translated into Bengalee and English. Compiled by critical thinking as an strategy Neel-Rutna Haldar.

Second Edition [Neel-Rutna Haldar, compiler] [John Clark Marshman, translator] Serampore: [Mission Press], 1830. John Clark Marshman's Advertisement prefacing this work is dated March, 1830. He indicated that this edition follows a first edition which Haldar had printed at and contrast, a private press. Marshman's translation, amounting to an indepedent work of the sort for which authors today would claim publication credit, represents yet another of his previously unnoticed contributions to the Serampore enterprise. [Leyden, John]. A Comparative Vocabulary of the Barma, Malyu and T'hi Languages. Serampore : Printed at the Mission Press, 1810.

Schroeter, Frederic Christian Gotthelf. A Dictionary of the Bhotanta or Boutan Language. Printed from a Manuscript Copy Made by the Late Frederic Christian Gotthelf Schroeter. Thinking Instructional. Edited by John Marshman. To Which is Prefixed A Grammar of the Bhotanta Language. Edited by W. Carey. Serampore: s.n., 1826. Select Papers on the Subject of Expressing the Languages of the East in the English Character: Extracted from the hamlet, Periodicals Published at critical thinking was used instructional strategy, Calcutta, in the Early Part of the Year 1834. [Serampore] : Serampore Press, 1834. * Shakespear, John. Beauty Essay. A Dictionary of Hindustani and English.

By John Shakespear, Oriental Professor at the Honourable East-India Company's Military Seminary. Second Edition, Much Enlarged. London: Printed for the Author. By Cox and critical was used instructional Baylis, 75, Great Queen-Street, Lincoln's Inn Fields, And Sold by Black, Kingsbury, Parbury, and Allen, Booksellers to the Honourable East-India Company, Leadenhall Street, 1820. *Singha, Umura. Kosha, or Dictionary of the law homework help online, Sungskrita Language. By Umura Singha. With an English Interpretation and Annotations by H. T. Colebrooke, Esq. Second Edition. Serampore: , 1825. *Taberd, Jean Louis, ed., Episcopo Isaropolitano, Vicario Apostolico Cocincin , Cambdoi et Ciamp , Asiatic Societatis Parisiensis, nec non Bengalensis Socio Honorario. Dictionarium Anamitico-Latinum, Primitus Inceptum ab Illustrissimo ed Reverendissimo P[ierre].

J[oseph]. Pigneaux, Episcopo Adranensi, Vicario Apostolico Cocincin , c . Fredericnagori Vulgo Serampore, ex typis J. C. Marshman, 1838 [electronic edition]. *Takoor, Mohunpersaud, Assistant Librarian in the College of Fort William. Critical As An Instructional Strategy. A Vocabulary, Bengalee and English, For the Use of Students. Calcutta: Printed by Thomas Hubbard, At the Hindoostanee Press, 1810 [electronic edition]. One hundred copies of this book were printed, and this copy exists in the Bibliotheca Regia Monacensis [ Bayerische Staatsbibliothek, Munich ]. The dedication page in this book reads: To The Rev. W. Questions. Carey, D.D.

Professor of the Bengalee, Sunscrit, and Marhatta Languages, in the College of Fort William, This Work, Is Most Respectfully Dedicated By his most Obedient Humble Servant, Mohunpersaud Takoor. Calcutta, Jan. 1st, 1810. *________. Thinking Strategy. A Vocabulary, Ooriya and English, For the Use of Students. Serampore: Printed at the Mission Press, 1811. Ap Essay Questions Hamlet. According to Graham W. Shaw, The Cuttack Mission Press and critical was used Early Oriya Printing, British Library Journal 3/1 (1977): 34, this work by Takoor was The first vocabulary of Oriya. --Bennie R. Crockett, Jr. *Trevelyan, Charles E., James Prinsep, John Tytler, Alexander Duff, Henry Thoby Prinsep. The Application of the Roman Alphabet to All the Oriental Languages; Contained in a Series of Papers, Written by Messrs. Trvelyan, J. Prinsep and Tytler, Rev.

A Duff, and ap essay questions hamlet Mr. Critical Thinking Was Used Strategy. H. T. Prinsep, and Published in Various Calcutta Periodicals in the Year 1834. [Serampore]: From the Serampore Press, 1834. [ Turner, Sharon]. Wilkins's, Carey's, and Colebrooke's Grammars of the Sanskrit Language, The Quarterly Review 1, no. 1. February, 1809: 53-69. *[Turner, Sharon]. Walk Small. ART. VII.

The Ramayuna of Valmeeki, translated from the original Sungskrit, with explanatory Notes . By William Carey and Joshua Marshman. 4to. Vol. I, Containing the first Book. pp. 449, The Quarterly Review 3, no. 6. May, 1810: 379-388. *Yates, William. A Grammar of the Sunscrit Language, On a New Plan. By William Yates. Calcutta: Printed and Sold at the Baptist Mission Press. Sold also by Messrs.

Black, Parbury, and Allen, Leadenhall Street, London, 1820. Created: December 20, 2000 Updated: April 24, 2017.

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COMPUTER GAME DEVELOPMENT: AN INSTRUCTIONAL STRATEGY …

Smalls-Mantey, Sample F31 Application and Summary Statement. We are truly indebted to the grantee who allowed us to as an instructional strategy, post this outstanding F31 sample application to help the next generation of investigators write applications. The F31 sample application below doesn’t reflect the complex layouts of the actual SF 424 PDF forms. Instead, we’ve provided a list of key fields from cheap, those forms and the applicant’s responses. In addition, we redacted some applicant-specific information such as contact information, publications in press, and budget specifics. The text of this application is critical thinking was used as an strategy, copyrighted. You may use it only for nonprofit educational purposes provided the document remains unchanged and the PI, the grantee organization, and NIAID are credited. Questions?

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However, this approach has not been successful in on high and college containing viral replication in vaccinees that have become HIV-infected. Antibody-dependant cellular cytotoxicity (ADCC) has been shown to critical thinking was used, mediate sterilizing immunity against challenge with pathogenic simian immunodeficiency virus [Hessel 2007]. In ADCC, Fc-bearing Abs bind viral epitopes coating an infected CD4+ target T cell and an Fc receptor bearing effector, most commonly natural killer cells (NKs), bind the Ab and use perforin to deliver granzymes which induce apoptosis in about abigail the target. We want to study ADCC in infected patients to understand the magnitude and characteristics of the was used instructional, best responses achieved by natural infection. First, we will compare ADCC mediated by the sera of a cohort of morning walk small essay patients using a granzyme B cytotoxicity assay developed in our lab. Critical Instructional Strategy. Based on physical essay these findings, we will select the sera of patients with the most ADCC, generate monoclonal Abs (mAbs), and characterize the mAbs based on epitope specificity, affinity, potency, breadth, IgG isotype, and Fc type.

We will also evaluate whether ADCC is disparate from classical neutralization. Finally, we will use microscopy to examine the synapse between effectors, Abs, and targets. The outcome of this research will provide insight into the characteristics of Abs that mediate ADCC that are likely important goals in the design of HIV vaccines or immunotherapies. Hypothesis: Antibody-dependent cellular cytotoxicity (ADCC) is a function that has been shown to mediate protection from lentiviral infection. We hypothesize that variations in ADCC activity of sera are dictated by critical was used instructional the amount, specificity, and about subclass of HIV-specific antibodies. Aim 1 : Characterize the potency of sera of HIV-infected individuals in ADCC. Aim 2 : Characterize the specificity and breadth of thinking was used as an antibodies with ADCC activity. Aim 3 : Characterize the structure and law homework help function of the target-effector synapse using both fixed and live cell laser scanning confocal microscopy (LSCM), transmission electron microscopy (TEM) and cryo-electron microscopy (cryo-EM) and tomography. Understanding the critical thinking was used, role of antibody-dependent cellular cytotoxicity (ADCC) in HIV could provide important insights for ap essay questions hamlet, induction of thinking was used as an instructional strategy this activity through vaccination.

This project seeks to characterize the Abs that mediate ADCC and law homework help image the functional synapse formed by cellular components involved in ADCC with the goal of defining new goals for thinking strategy, the development of HIV vaccines and therapeutics. Gallo RC, Salahuddin SZ, Popovic M. Frequent detection and isolation of cheap cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for was used strategy, AIDS. Science. 1984; 224: 500-3. Barre-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, et al. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).

Science. 1983; 220(4599): 868-71. Organization WH. Global summary of the physical beauty definition essay, AIDS epidemic, December 2007. 2007 [cited 2009 September 18, 2009]; Hessell AJ, Hangartner L, Hunter M, Havenith CE, Beurskens FJ, Bakker JM, et al. Fc receptor but not complement binding is important in critical thinking as an instructional antibody protection against HIV. Nature. Beauty Definition. 2007; 449(7158): 101-4. www.hivresearh.org. RV144 Phase III HIV Vaccine Trial Press Release. 2009. Chung A, Rollman E, Johansson S, Kent SJ, Stratov I. The utility of ADCC responses in HIV infection.

Current HIV research. 2008; 6(6): 515-9. Strategy. Kohl S, Starr SE, oleske JM, Shore SL, Ashman RB, Nahmias AJ. Human monocytemacrophage- mediated antibody-dependent cytotoxicity to herpes simplex virus-infected cells. J Immunol. 1977; 118(3): 729-35. School. Forthal DN, Landucci G. In vitro reduction of virus infectivity by antibody-dependent cellmediated immunity. Journal of immunological methods. Thinking Was Used Instructional. 1998; 220(1-2): 129-38.

Stratov I, Chung A, Kent SJ. Robust NK cell-mediated human immunodeficiency virus (HIV)-specific antibody-dependent responses in the crucible essays HIV-infected subjects. J Virol. 2008; 82(11): 5450-9. Gomez-Roman VR, Florese RH, Patterson LJ, Peng B, Venzon D, Aldrich K, et al.

A simplified method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity. Critical Thinking Was Used Instructional Strategy. Journal of immunological methods. 2006; 308(1-2): 53-67. Migueles SA, Osborne CM, Royce C, Compton AA, Joshi RP, Weeks KA, et al. Lytic granule loading of cheap essay CD8+ T cells is required for critical thinking was used as an strategy, HIV-infected cell elimination associated with immune control. Immunity. A Comparison And Contrast On High. 2008; 29(6): 1009-21. Vago L, Perna SK, Zanussi M, Mazzi B, Barlassina C, Stanghellini MT, et al. Loss of mismatched HLA in leukemia after stem-cell transplantation.

N Engl J Med. Was Used Instructional. 2009; 361(5): 478- 88. Ziegner U, Campbell D, Weinhold K, Frank I, Rutstein R, Starr SE. Deficient antibodydependent cellular cytotoxicity against human immunodeficiency virus (HIV)-expressing target cells in perinatal HIV infection. Physical Beauty. Clin Diagn Lab Immunol. As An Strategy. 1999; 6(5): 718-24. Brunetta E, Fogli M, Varchetta S, Bozzo L, Hudspeth KL, Marcenaro E, et al. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer cell subsets associated with high levels of help online HIV-1 viremia. Blood.

2009. Ljunggren HG, Ohlen C, Hoglund P, Yamasaki T, Klein G, Karre K. Afferent and efferent cellular interactions in thinking instructional strategy natural resistance directed against MHC class I deficient tumor grafts. J Immunol. 1988; 140(2): 671-8. De Maria A, Ferraris A, Guastella M, Pilia S, Cantoni C, Polero L, et al. Expression of HLA class I-specific inhibitory natural killer cell receptors in a comparison essay on high school HIV-specific cytolytic T lymphocytes: impairment of specific cytolytic functions. Proceedings of the National Academy of Sciences of the United States of America.

1997; 94(19): 10285-8. Ahmad R, Sindhu ST, Toma E, Morisset R, Vincelette J, Menezes J, et al. Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and critical thinking was used as an instructional prognostic predictors of HIV infection. Law Homework Online. J Clin Immunol. 2001; 21(3): 227-33. Lambotte O, Ferrari G, Moog C, Yates NL, Liao HX, Parks RJ, et al. Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers.

AIDS. 2009; 23(8): 897-906. Dalgleish A, Sinclair A, Steel M, Beatson D, Ludlam C, Habeshaw J. Failure of thinking as an strategy ADCC to predict HIV-associated disease progression or outcome in a haemophiliac cohort. Clin Exp Immunol. 1990; 81(1): 5-10.

Koup RA, Sullivan JL, Levine PH, Brewster F, Mahr A, Mazzara G, et al. Antigenic specificity of antibody-dependent cell-mediated cytotoxicity directed against human immunodeficiency virus in antibody-positive sera. J Virol. 1989; 63(2): 584-90. Doria-Rose NA, Connors M. Antibody-secreting B cells in HIV infection. Curr Opin HIV AIDS. 2009; 4(5): 426-30.

Burke B, Barnett SW. Broadening our view of protective antibody responses against HIV. Current HIV research. 2007; 5(6): 625-41. Sattentau Q. Avoiding the void: cell-to-cell spread of human viruses.

Nat Rev Microbiol. 2008; 6(11): 815-26. Chamow SM, Zhang DZ, Tan XY, Mhatre SM, Marsters SA, Peers DH, et al. A humanized, bispecific immunoadhesin-antibody that retargets CD3+ effectors to questions, kill HIV-1- infected cells. J Immunol. 1994; 153(9): 4268-80. Jolly C, Kashefi K, Hollinshead M, Sattentau QJ. HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse. J Exp Med. 2004; 199(2): 283-93. Groot F, Welsch S, Sattentau QJ.

Efficient HIV-1 transmission from macrophages to critical was used as an strategy, T cells across transient virological synapses. A Comparison Essay On High School And College. Blood. 2008; 111(9): 4660-3. Martin N, Welsch S, Jolly C, Briggs JA, Vaux D, Sattentau QJ. Virological synapsemediated spread of human immunodeficiency virus type 1 between T cells is sensitive to entry inhibition. J Virol. 2010; 84(7): 3516-27. Intellectual Support : My mentors Mark Connors and Quentin Sattentau are leading experts in as an instructional strategy their field and have mentored numerous people that have gone on to successful careers in science. Help. This dual mentorship will teach me to aggressively approach science from two distinctive perspectives in my graduate career, something most PhD scientist don’t experience until their first post-doctoral experience.

While at critical thinking as an strategy, NIH I will have received extensive support of staff from Richard Siegel, Director of the essay help, NIH MD/PhD partnership program and Michael Lenardo, Director the NIH/Oxford/Cambridge Scholars Program. Critical Instructional Strategy. While at help, Oxford I will have the guidance of Lucinda Risius, Managing Director of the Graduate Pathology Program and I will also be assigned a departmental advisor, outside of my lab, with whom I can discuss my research Progress. Educational Resources : Through the FAES at NIH I have access to courses to improve lab specific skills and foundation knowledge. Thinking Strategy. I have already participated a Vaccine Development course. At Oxford I will take seminars at the Centre for Excellence in Teaching and Learning for training in teaching skills.

I will also take courses pertinent to my research offered at the Dunn School of Pathology. Both the morning walk, NIH and thinking was used as an instructional strategy Oxford have libraries and IT staff that can aid me in scholarly research. Physical Resources : Both labs have sufficient funding to provided me any reagent/equipement need for a comparison and contrast on high school, the proposed research. Lab Space – I am provided with a desk and was used as an instructional personal desktop computer. Law Homework Help. Bench space is shared within the lab. Safety – In order to ensure our safety from hazardous blood samples we work under laminar flow hoods in a P2 facility with P3 practices. Samples – We receive blood samples from patients enrolled within our protocol. We also have access to the NIH blood blank for normal human blood samples. As provided by Quentin Sattentau: “Oxford University is held in high international regard for its strong teaching and thinking was used as an instructional research background and its unique and personal teaching style.

Within the University the and contrast essay school and college, Department of Pathology has an excellent reputation for graduate teaching, and has achieved 100% success in DPhil graduation within 4 years for the past 3 years. The Department has a strong graduate support structure, in which each student has a principal supervisor, the possibility of a cosupervisor, a departmental advisor, and a college advisor. The supervisor(s) will generally meet with the student multiple times a term, and each of the non-supervisory mentors will meet with the candidate approximately once a term and will file reports on the candidate’s progress. Was Used As An. The candidate will be expected to cheap essay, attend a series of high profile external seminars that take place once a week in term time, and a regular series of internal seminars from leading and more junior University and Departmental investigators and students. Thinking As An Strategy. Adjoa will attend and physical beauty participate in the weekly lab journal club, in critical thinking as an which scientific papers are taken apart critically by members of the law homework, group, and a weekly laboratory meeting in which each lab member presents their ongoing research. Thinking Instructional Strategy. Adjoa will also be encouraged to chat to cheap essay, other members of the department during tea lunch and coffee breaks, a longstanding Oxford institution! The Department has a fully equipped quiet library for literature research and thinking as an strategy other reading and writing. Adjoa will have her own writing up space close to her work bench, equipped with a portable computer and if required, an essays about abigail external screen.

Adjoa will have full access to all core facilities, including the imaging suite with multiple light microscopes, a flow cytometry and sorting suite, an electron microscopy facility with full technical and scientific support. We also have strong connections with the biochemistry and chemistry departments and the Weatherall Institute of Molecular Medicine at the John Radcliffe Hospital for obtaining clinical samples and critical expertise.” BD FACSAria IIu. BD Pathways 855. VICTOR Light luminescence plate reader. AutoMACS Pro Separator. AutoMACS Classic Separator.

Containment II/III Laboratory with 4 tissue culture hoods. Tissue culture. The laboratory has a new tissue culture facility comprised of 8 double hoods and associated incubators and ancillary equipment that is shared with three other virology groups. Virology. The department has a large, fully-equipped containment-III laboratory shared between two groups, with three tissue culture hoods and associated incubators and ancillary equipment, in cheap essay which HIV-1 is grown and was used as an strategy used to infect cells. Flow cytometry. The department has a core flow cytometry facility with three BD analyzers (2 x FACScalibur 2 x LSR2) and two sorters. Molecular biology. Walk. The Sattentau laboratory has all facilities for molecular biology carried out under containment levels –I, -II and –III. Light microscopy.

The department has 5 confocal microscopes of varying sophistication and critical thinking was used as an strategy resolution, two of which are set up for live cell immunofluorescence work. The department has three recently acquired high-speed CCD cameras and associated microscopes for live cell immunofluorescence analysis. Questions. The Sattentau laboratory has a Zeiss Pascal confocal microscope and a new CCD camera set up with a Zeiss Axiovert 200 microscope for fixed and live cell work in critical thinking as an instructional the containment-III laboratory, allowing real time analysis of live, infected cells. Electron microscopy. The department has two transmission electron microscopes and a scanning electron microscope, all of which are maintained and run as a central service facility by a skilled dedicated operator. Our collaborator in Oxford (Kay Grunewald) is located at the University Churchill campus, which is 4 miles from the Pathology Department. He maintains and uses 3 microscopes set up for the crucible essays, cryo-tomography as follows.

300keV FEG cryo-electron microscope FEI TF30 Helium Polara with GIF2002 imaging filter (2 x 2k CCD) 300keV FEG cryo-electron microscope FEI TF30 with 4 x 4kCCD 120keV cryo-electron microscope FEI T12 with 4 x 4k CCD. Research Related Senior/Key Person Profile. [Our Web version of this sample application can't reproduce the layout of the actual PDF forms. See below for the biographical sketch attachments.] My interest in studying infectious diseases stems from the 2001 anthrax scare in the Washington D.C. area. I already had a strong interest in science but through my participation in the Gene Search Science Project at strategy, Catholic University the following summer I came to understand how medical research impacts treatment for and contrast school, routine illnesses and also plays a role in national defense. Since middle school I have been preparing for a career in science. At Eleanor Roosevelt High School I was enrolled in thinking was used as an the rigorous Science and Technology Program during which time in walk essay participated in the Gene Search Project and researched biochemical pathways that influence sickle cell anemia with Dr. Instructional Strategy. William Winters at Howard University Hospital. Cheap Help. This experience taught me how research and critical thinking instructional medicine are intertwined and inspired me to become a physicianscientist. At UMBC I was a member of the Meyerhoff Scholars Program and an HHMI Undergraduate Research Scholar where numerous lab experiences, seminars, rigorous classes, and multiple opportunities for definition essay, scientific presentations prepared me for a career as a scientist.

My lab skills and understanding of a research career increased exponentially during my four years in Michael Summers’ lab. Not only did I learn about protein purification, gel electrophoresis, NMR, and ITC while studying MuLV RNA packaging, but more importantly of the time and discipline necessary for excellent research and critical the internal drive that keeps one focused. Working with Dr. Nikola Pavletich I learned the value of walk immediately organizing my data so that others could analyze my results quickly. In the lab of Tom Cech I had the responsibility of designing a new protocol to study telomerase assembly, a skill that has enabled me to design a novel assay to investigate AIDS specific questions in my graduate studies. The medical education I’ve received at critical thinking was used instructional strategy, Columbia has given me a unique perspective with which I approach scientific questions. Cheap Essay. Under the tutelage of Mark Connors and Quentin Sattentau, leaders in their fields on nonprogressive HIV infection and as an strategy viral transmission, my understanding of infectious disease and my capacity to pursue further research in these fields will be greatly enhanced. In addition, the courses, medical preceptorships, presentations, teaching, and career development activities I am undertaking in the forthcoming years make me an excellent P.I. for this grant.

Academic and Professional Honors. 2003 National Urban League Scholarship 2003 UMBC Meyerhoff Scholar 2003 UMBC Honors College 2003 HHMI Undergraduate Research Scholar 2004 NAD Distinguished Youth Award 2005 UMBC Minority Access to and contrast school, Research Careers Scholar 2005 Abby Rockefeller Mauze Award Charitable Trust Scholar for Outstanding Achievement 2006 Goldwater Scholar 2007 UMBC Top Senior Biochemistry Major 2007 Graduated Sum Cum Laude from UMBC 2007 NIH/Oxford/Cambridge Scholar 2010 International AIDS Vaccine Conference Scholarship 2011 Keystone Symposia Underrepresented Minority Scholarship. 2004 Omicron Delta Kappa Leadership Honor Society 2004 Golden Key International Honor Society, Sophomore/Alumni Director 2007 Phi Beta Kappa. Dey A, York D, Smalls-Mantey A, Summers MF. 2005. Composition and sequence-dependent binding of RNA to the nucleocapsid protein of Moloney murine leukemia virus. Critical Was Used Instructional Strategy. Biochemistry.

44(10), 3735-3744. Miyazaki Y, Irobalieva RN, Tolbert BS, Smalls-Mantey A, Iyalla K, Loeliger K, D'Souza V, Khant H, Schmid MF, Garcia EL, Telesnitsky A, Chiu W, Summers MF. 2010. Structure of help a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography. Critical Was Used Instructional. J Mol Biol.

404(5), 751-772. Smalls-Mantey A, Winter W. 2003. Biosynthesis of 2,3-diphosphoglycerate in Erythrocytes. Poster presentation at ERHS Science Fair and Prince Georges County Science Fair. March 2003. Smalls-Mantey A, Dey, A, Phillip C, Summers MF.

2004. Characterization of High-Affinity Nucleocapsid Protein Binding Sites Within the Moloney Murine Leukemia Virus RNA Packaging Signal. Poster presented at 2004 Annual Biomedical Research Conference for Minority Students, November 2004. Smalls-Mantey A, Min J, Pavletich N. 2005. Structural and Biochemical Studies of the Yeast Rad4-Rad23 Complex Bound to DNA. Essays About Abigail. Poster presented at Tri-Institutional Gateways to the Laboratory Program Symposium and 2005 Leadership Alliance.

August 2005. Smalls-Mantey A, Miyazaki Y, Summers MF. 2007. Dimerization of Moloney Murine Leukemia Virus Nucleocapsid Protein Binding Sites Facilitates Binding. Poster presented at 2007 UMBC Undergraduate Research and Creative Achievement Day. April 2007. Instructional. Smalls-Mantey A, Klein R, Doria-Rose N, Laub L, Rood J, Migueles S, Sattenatu. 2010. HIV-Specific Antibodies Mediate Rapid Antibody-Dependent Cellular Cytotoxicity Against Primary HIV-Infected CD4+ T Cells.

Poster presented at 2010 Keystone HIV Vaccines (X5) Meeting. March 2010. Smalls-Mantey A, Klein R, Doria-Rose N, Laub L, Rood J, Migueles S, Sattenatu. Help. 2010. HIV-Specific Antibodies Mediate Rapid Antibody-Dependent Cellular Cytotoxicity Against Primary HIV-Infected CD4+ T Cells. Poster presented at 2010 Oxford Pathology Department Graduate Student Symposium.

June 2010. Smalls-Mantey A, Klein R, Doria-Rose N, Laub L, Rood J, Migueles S, Sattenatu. 2010. HIV-Specific Antibodies Mediate Rapid Antibody-Dependent Cellular Cytotoxicity Against Primary HIV-Infected CD4+ T Cells. Poster presented at 2010 NIH/Oxford/Cambridge Scholars Research Colloquium. Smalls-Mantey A, Klein R, Doria-Rose N, Laub L, Rood J, Migueles S, Sattenatu. 2010. HIV-Specific Antibodies Mediate Rapid Antibody-Dependent Cellular Cytotoxicity Against Primary HIV-Infected CD4+ T Cells.

Poster presented at critical thinking as an instructional strategy, 2010 International AIDS Vaccine Conference. September 2010. Smalls-Mantey A. 2010. Antibody-Dependent Cellular Cytotoxicity and the Control of HIV. Talk given at Frontiers in Biomedicine NIH/Oxford/Cambridge Scholars Program student presentation series. November 2010. [Outside research support redacted from sample.] A. Personal Statement Regarding Project. Currently HIV-specific ADCC is considered one of the very top priorities in the field of HIV-specific immunity. Our laboratory has assembled the best techniques and reagents in the field to carry out this project.

We have extensive experience in cheap HIV-specific antibodies and cytotoxicity. In addition we have a long track record of training students to prepare them for a carreer in biomedical research. 1985 - 1986 Intern in Pediatrics, The Boston Floating Hospital, New England Medical Center, Boston, Massachusetts 1986 - 1988 Resident in as an Pediatrics, The Boston Floating Hospital, New England Medical Center, Boston, Massachusetts 1988 – 1989 Chief Resident in Pediatrics, The Boston Floating Hospital, New England Medical Center, Boston, Massachusetts July 1989 - October 1989 Medical Staff Fellow, Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of essay help Health, Bethesda, MD October 1989 - June 1993 U.S. Public Health Service, Research Associate (C.O.), Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD July 1993 - June 1994 U.S. Public Health Service, Clinical Associate, Clinical Center, National Institute of critical thinking was used strategy Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD January 1994 - June 1994 Clinical Fellow in ap essay questions hamlet Infectious Diseases, The Childrens Hospital of Philadelphia, Philadelphia, PA. June 1994 - December 2004 U.S.

Public Health Service, Medical Officer, National Institute of Allergy and as an strategy Infectious Diseases, Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD December 2007- Present Chief, HIV-Specific Immunity Section, Laboratory of law homework Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. Recent Honors and Editorial and Review Board Activities. 2009 - U.S. Public Health Service Outstanding Service Medal 2009 - present Vaccine Production Development Team Scientific Advisory Board, University of thinking was used as an instructional Pennsylvania 2009 - present HIV Enterprise Host Genetics and HIV Diversity Working Group 2010 - present Editorial Board, Journal of Virology. C. Help Online. Peer-Reviewed Publications. Migueles SA, Sabbaghian MS, Shupert WL, Bettinotti MP, Marincola FM, Schwartz D, Sullivan J, and Connors M. HLA B*5701 is highly associated with restriction of thinking strategy virus replication in a subgroup of HIV infected long term nonprogressors. PNAS 2000; 97(6): 2709-2714. Ap Essay Questions Hamlet. Migueles SA, Laborico AC, Shupert WL, Sabbaghian MS, Rabin R, Hallahan C, Van Baarle D, Kostense S, Miedema F, McLaughlin M, Ehler L, Metcalf J, Liu S, and Connors M. HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nature Immunol 2002; 3(11); 1061-1068. Migueles SA, Laborico AC, Imamichi H, Shupert WL, Royce C, McLaughlin M, Ehler L, Metcalf J, Liu S, Hallahan CW, and Connors M. The differential ability of HLA B*5701+ long-term nonprogressors and thinking was used instructional strategy progressors to restrict HIV replication is not caused by loss of cheap recognition of autologous viral gag sequences.

J Virol 2003; 77(12); 6889-6898. Iyasere C, Tilton JC, Johnson AJ, Younes S, Yassine-Diab B, Sekaly RP, Kwok WW, Migueles SA, Laborico AC, Shupert WL, Hallahan CW, Davey RT Jr., Dybul M, Vogel S, Metcalf J, and Connors M. Diminished proliferation of thinking HIV-specific CD4+ T Cells is associated with diminished IL-2 production and recovered by exogenous IL-2. J Virol 2003; 77(20); 10900-10909. Tilton JC, Luskin MR, Johnson AJ, Manion M, Hallahan CW, Metcalf JA, McLaughlin M, Davey RT Jr., and Connors M. Changes in paracrine IL-2 requirement, CCR7 expression, frequency, and cytokine secretion, of ap essay hamlet HIV-specific CD4+ T cells are a consequence of antigen load. J Virol 2007; 81;2713-2725. Migueles SA, Osborne CM, Royce C, Compton AA, Joshi RP, Weeks KA, Rood JE, Berkley AM, Sacha JB, Cogliano-Shutta NA, Lloyd M, Roby G, Kwan R, McLaughlin M, Stallings S, Rehm C, O’Shea MA, Mican J, Packard B, Komoriya A, Palmer S, Wiegand AP, Maldarelli F, Coffin JM, Mellors JW, Hallahan CW, Follman DA and Connors M. Lytic Granule Loading of CD8+ T-Cells is Required for HIV-Infected Cell Elimination Associated with Immune Control. Critical Strategy. Immunity 2008; 29 (6): 1009-1021. Definition Essay. Migueles SA, Weeks KA, Nou E, Berkley AM, Rood JE, Osborne CM, Hallahan CW, Cogliano-Shutta NA, Metcalf JA, McLaughlin M, Kwan R, Mican JM, Davey RT Jr, Connors M. Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy. J Virol 2009 83(22): 11876-11889. Doria-Rose NA, Klein R, Daniels M, O'Dell S, Nason M, Lapedes A, Bhattacharya T, Migueles S, Wyatt RT, Korber BT, Mascola JR, Connors M. Breadth of HIV-Specific neutralizing activity in sera: clustering analysis and association with clinical variables. J Virol 2009 84(3): 1631-1636.

Doria-Rose NA and thinking was used Connors M. Antibody-secreting B cells in HIV infection. Curr Opin HIV AIDS 2009 4:426-430 Wu X, Yang ZY, Li Y, Hogerkorp CM, Schief WR, Seaman MS, Zhou T, Schmidt SD, Wu L, Xu L, Longo NS, McKee K, O'Dell S, Louder MK, Wycuff DL, Feng Y, Nason M, Doria-Rose N, Connors M, Kwong PD, Roederer M, Wyatt RT, Nabel GJ and Mascola JR. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Ap Essay Questions. Science 2010 329:856-861. Migueles SA and Connors M. Long-term nonprogressive disease among untreated HIV-infected individuals: clinical implications of understanding immune control of HIV. Critical Was Used Instructional Strategy. JAMA 2010 304:194-201. The Crucible About Abigail. [Redacted publication in critical thinking was used as an instructional strategy press]

The research direction of the HIV-Specific Immunity Section of the Laboratory of Immunoregulation is focused upon mechanisms of immunity to help online, HIV. The laboratory is staffed by PhD and MD scientists with extensive experience in critical as an strategy the humoral or cellular immune response to a comparison essay on high and college, HIV. Strategy. In addition we have close collaborations with investigators at the NIAID Vaccine Research Center in the area of structure-function relationships of HIV-specific antibodies. Our laboratory is well equipped with multi-laser flow cytometers, automated magnetic sorters, and imaging equipment to carry out this project. Our laboratory is supported by the research budget of the Division of Intramural Research. Over the past 4 years we have received supplemental funding from the Intramural AIDS Targeted Antiretroviral Program (IATAP).

This will continue for the next 2 years. We have also received funding from the Office of physical beauty AIDS Research for work on was used instructional the humoral response to HIV. Positions and essay school Employment. 1985 - 1992 Lecturer, Department of thinking was used as an instructional Genito-Urinary Medicine, University College London, UK 1989 - 1991 Visiting scientist, Howard Hughes Medical Institute, Columbia University, New York, NY 1992 - 1998 Staff scientist (Director of Research), Centre d’Immunologie, Marseille, France 1999 - 2003 Reader, Section of law homework Infectious Disease, Imperial College London, London UK 2003 - Professor of immunology, Department of Pathology, University of Oxford, Oxford UK. Other Experience and Professional Memberships. 1995 - Member, American Association for the Advancement of Science 1998 - Member, American Society for Microbiology 1998 - Member, British Society for Immunology, UK 1998 - Member, Society for critical thinking was used instructional strategy, General Microbiology, UK 2005 - Member of the Pasteur Institute Paris France Scientific Evaluation Committee. 2005 - Member of the Vaccine Research Center (VRC) NIH Board of the crucible essays abigail Scientific Councilors 2007 - Member of BMGF Vaccine Monitoring Centre SAB 2008 - Member of NIH HIVRAD/Novartis Neutralizing Antibody Vaccine Consortium SAB 2009 - Member of study section for Swedish Program for International Development 2010 - Member of NIH study section for the B cell Immunology Partnership Program for thinking was used, HIV-1 Vaccine Discovery (U19) C. Selected Peer-Reviewed Publications. Most relevant to the current application. Martin N, Welsch S, Jolly C, Briggs JA, Vaux D and Sattentau QJ. (2010) Virological synapse-mediated spread of essay help human immunodeficiency virus type-1 between T cells is sensitive to critical thinking as an strategy, entry inhibition.

J. Virol. 84: 3516-3527. Gonzalez N, Bermejo M, Calonge E, Jolly C, Arenzana-Seisdedos F, Pablos JL, Sattentau QJ and Alcami J. (2010) SDF-1/CXCL12 production by mature dendritic cells inhibits the propagation of X4-tropic HIV-1 isolates at the dendritic cell-T-cell infectious synapse. J Virol. On High School And College. 84:4341-51 Groot F, Welsch S and Sattentau QJ. (2008).

Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses. Blood 111: 4660-4663. Was Used Instructional Strategy. Sowinski S, Jolly CJ, Berninghausen O, Purbhoo, MA, Chauveau A, Kohler K, Oddos S, Eissmann P, Brodsky FM, Hopkins C, Onfelt B, Sattentau QJ and Davis DM (2008). Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission. Nature Cell. Morning Walk Small Essay. Biol. 10: 211-219. Jolly C and Sattentau QJ (2007).

HIV-1 assembly, budding and cell-cell spread in T cells takes place in as an instructional tetraspanin-enriched plasma membrane. J. Virol. 81:7873-7884 Jolly C and Sattentau QJ (2007). Adhesion molecule interactions facilitate human immunodeficiency virus type-1-induced virological synapse formation between T cells. J. Law Homework Online. Virol.

81: 13916-13921. Critical Thinking As An Instructional Strategy. Jolly C, Mitar I and Sattentau QJ (2007). Requirement for an intact actin and tubulin cytoskeleton for efficient HIV-1 assembly and spread. J. Virol. 81: 5547-6 Jolly C and ap essay Sattentau QJ. Human Immunodeficiency virus type-1 virological synapse formation in T cells requires lipid raft integrity.

J. Virol. 2005 79: 12088-12094. Jolly C, Kashefi K, Hollinshead M and Sattentau QJ (2004) HIV-1 cell-to-cell transfer across an instructional Env-induced, actin-dependent synapse. J. Exp Med. Walk Essay. 199: 283-193. Additional recent publications of important to critical thinking instructional, the Field (in chronological order) Wegmann F, Krashias G, Luhn K, Laamanen K, Vieira S, Jeffs SA, Shattock RJ and Sattentau QJ (2011) A novel strategy for inducing enhanced mucosal HIV-1 antibody responses in an anti-inflammatory environment.

PlosOne 6: e15861. Kong L, Sheppard N, Stewart-Jones G, Robson CL, Chen H, Xu X, Krashias G, Bonomelli C, Scanlan CN, Kwong PD, Jeffs SA, Jones IM, Sattentau QJ (2010) Expression system-dependent modulation of HIV-1 envelope glycoprotein antigenicity and immunogenicity. Law Homework Help Online. J. Mol. Biol. Aug 25th epub. Krashias G, Simon K, Wegmann F, Kok WL, Ho LP, Stevens D, Skehel J, Heeney JL, Moghaddam AE and Sattentau QJ. (2010). Potent adaptive immune responses induced against thinking as an strategy HIV-1 gp140 and influenza virus HA by a polyanionic carbomer. Definition Essay. Vaccine 28: 2482-2489.

Zanetti G, Briggs JAG, Grunewald K, Sattentau QJ and Fuller SD. SIV spike glycoprotein structure in situ determined by cryo-electron tomography. Plos Pathogens August 2 (8): e83 Sheppard NC, Bates AC and Sattentau QJ (2007). A functional human IgM response to HIV-1 Env after immunization with NYVAC-HIV C. AIDS 19: 524-527. [Outside research support redacted from thinking was used instructional, sample.] PHS Fellowship Supplemental Form, Research Plan.

[Our Web version of this sample application can't reproduce the layout of the actual PDF forms. Beauty Essay. The attachments are included below. Critical Thinking Was Used As An Instructional Strategy. In the original version, these attachments met the page limits.] Understanding the a comparison and college, basis of an immune response that controls infection or provides sterilizing immunity remains a major goal in the search for effective vaccines or immunotherapies for HIV. Critical Thinking Was Used Instructional. Antibodies (Abs) induced by candidate vaccines to the surface envelope glycoprotein have not neutralized a broad array of primary virus isolates. For this reason, eliciting a cytotoxic cellular response has been the help, primary goal in most recent vaccine trials. However, this approach has not been successful in containing viral replication in vaccinees that have become HIV-infected. Antibody-dependant cellular cytotoxicity (ADCC) has been shown to was used as an strategy, mediate sterilizing immunity against challenge with pathogenic simian immunodeficiency virus [Hessel 2007]. Questions. In ADCC, Fc-bearing Abs bind viral epitopes coating an infected CD4+ target T cell and an Fc receptor bearing effector, most commonly natural killer cells (NKs), bind the critical was used as an, Ab and use perforin to deliver granzymes which induce apoptosis in the target. We want to study ADCC in infected patients to essays about, understand the magnitude and critical thinking instructional characteristics of the best responses achieved by natural infection.

First, we will compare ADCC mediated by the sera of a cohort of patients using a granzyme B cytotoxicity assay developed in our lab. Based on these findings, we will select the sera of patients with the essay help, most ADCC, generate monoclonal Abs (mAbs), and characterize the mAbs based on epitope specificity, affinity, potency, breadth, IgG isotype, and Fc type. We will also evaluate whether ADCC is disparate from classical neutralization. Finally we will use microscopy to examine the synapse between effectors, Abs, and targets. Instructional Strategy. The outcome of this research will provide insight into the characteristics of Abs that mediate ADCC that are likely important goals in the design of HIV vaccines or immunotherapies.

Hypothesis: Antibody-dependent cellular cytotoxicity (ADCC) is a function that has been shown to mediate protection from lentiviral infection. We hypothesize that variations in ADCC activity of beauty essay sera are dictated by the amount, specificity, and thinking as an instructional subclass of HIV-specific antibodies. Aim 1 : Characterize the potency of sera of HIV-infected individuals in questions hamlet ADCC. In ADCC, Abs bind viral epitopes that are presented by infected CD4+ T cells. NKs expressing an Fc receptor bind the Fc domain of the Ab and was used as an instructional use perforin to deliver granzymes to the HIV-infected cell. Subsequently, granzymes induce apoptosis within the cell. Our lab has developed a flow cytometric assay that measures granzyme B delivered to cheap essay help, an HIV-infected CD4+ target T cell. We will classify ADCC by the percent of target cells receiving granzyme and the elimination of targets as defined by residual percent of targets expressing p24, HIV capsid. Compare the serum of HIV+ individuals with various rates of progression and viral loads to thinking was used as an instructional strategy, determine which contain Abs capable of mediating the highest levels of ADCC.

Compare the ADCC and neutralizing activity of patient sera. Aim 2 : Characterize the specificity and breadth of antibodies with ADCC activity. Our laboratory has panels of NAbs derived from patients with known serum neutralizing or ADCC-mediating activity. Determine whether recognition of specific epitopes is required for ADCC. Define the breadth of the polyclonal sera by its ability to mediate ADCC in CD4+ T cells infected by the crucible different clades of HIV. Titer serum total IgG, IgG1, and IgG3 binding infected CD4+ T cells. Aim 3 : Characterize the structure and function of the target-effector synapse.

Using both fixed and live cell laser scanning confocal microscopy (LSCM), transmission electron microscopy (TEM) and cryo-electron microscopy (cryo-EM) and tomography, we will examine the synapse formed between NK and other cells with potential ADCC activity (macrophages and neutrophils) and infected target cells. We will specifically investigate: The structure of a functional ADCC synapse. The kinetics of ADCC function in real time and thinking as an its relation to antibody type and online specificity. A role for antibody-dependent cell-mediated phagocytosis (ADCP) in thinking was used instructional elimination of HIV-infected cells. d. Receptors and effector molecules central to ADCC activity against HIV infected cells. Since being identified as the causative agent of AIDS in cheap essay help 1983, HIV infection has reached epidemic proportions with an estimated 2 million people worldwide dying from AIDS each year 1- 3. There is more public awareness about how to prevent HIV infection but with the growing incidence of HIV infection and the limitations of current antiretroviral therapy, there is an imperative need for a vaccine. One of the critical thinking was used as an strategy, most critical areas of walk small research on vaccines for HIV is the search for correlates of immunity. At present the only method for determining the critical was used as an instructional strategy, potential benefits of a vaccine with regard to protection from infection or lowering of cheap essay viral load upon critical was used as an instructional, infection remains very large clinical efficacy trials.

Determining correlates of immunity would tremendously accelerate the development process by physical beauty permitting some estimation of clinical efficacy prior to a Phase III trial. Reliable correlates would permit screening of vaccine candidates at critical was used as an strategy, a much earlier point in development with smaller numbers of participants. Over the past 20 years, research into correlates of immunity to HIV have largely focused on CD8+ cytotoxic T lymphocytes (CTLs) or neutralizing antibodies (NAbs). Law Homework. In addition to neutralization, antibodies (Abs) may fight viral infections by antibody-dependent cell-mediated phagocytosis (ADCP) or by antibody-dependent cellular cytotoxicity (ADCC). Critical Instructional Strategy. In ADCC, Abs bind viral epitopes presented on essay school infected target cells and Fc? receptor-bearing effector cells such as natural killer cells (NKs) recognize and bind the Fc? region of these Abs. Upon cross-linking of the Fc? receptor, NKs release perforin that punctures the target’s cell membrane and deliver proteases such as granzyme B (GrB) which induce apoptosis. ADCC has become a major focus within the thinking instructional strategy, field following two important studies highlighting its potential importance in providing immunity to HIV. A recent study by Burton and physical beauty essay colleagues demonstrated that neutralizing Abs with mutated Fc? receptor binding regions were less effective in protecting macaques from critical was used strategy, HIV whereas Abs with impaired complement binding conferred protection to macaques, suggesting that ADCC may be more important in preventing infection than neutralization or complement activation alone 4. Prior to this study, it was widely accepted that infection of a single cell would lead to integration and chronic infection. Essays Abigail. However, because ADCC mediated effects are on virus infected cells and not free virions, this study provided indirect evidence and instructional proof of the concept that ADCC can eliminate lentivirus-infected cells in vivo. In addition, some recent data in questions human efficacy trials has also greatly increased interest in ADCC as an important component of vaccine induced immunity to HIV.

In September 2009 data from the phase III RV144 (Thai) vaccine trial were released and showed that the critical was used strategy, prime-boost combination of ALVACR HIV and AIDSVAXR B/E reduced HIV infection. This vaccine regimen was known to not elicit a strong cellular or NAb response. It does, however, elicit binding antibodies that have suggested to the field that the essay help, protective efficacy is likely mediated through ADCC 5. Critical Thinking Was Used Instructional. Our laboratory is part of school and college a large international effort to instructional, characterize ADCC antibodies from this trial in order to essay, determine whether there were higher ADCC-mediating antibodies in uninfected vaccinees compared to those that were infected. Although HIV-specific ADCC is now considered an critical as an instructional strategy extremely important part of essays vaccineinduced immunity several basic questions regarding the critical instructional strategy, nature of an effective ADCC response have not been addressed. For example, the ap essay hamlet, number, affinity, and specificities of antibodies necessary to mediate ADCC remains poorly understood. Our laboratory has now developed assays that can accurately measure ADCC against HIV-infected cells. We also have assembled panels of monoclonal antibodies from individual patients that permit a characterization of individual antibodies that mediate HIV-specific ADCC. One of the initial goals of this project was to adapt our current killing assay to critical was used as an instructional, provide a more robust assay for HIV-specific ADCC. Past studies of physical beauty definition essay ADCC have been hampered by the availability of assays that are only partially quantitative. There are four primary methods that people use to measure ADCC 6. The most prevalent is the chromium release assays (CRA), which is highly variable, does not specifically account for instructional, the mechanism of killing, and is insufficiently quantitative 7. The ADCVI assay incubates targets, serum, and effectors for 24 hours and the supernatant is applied to the B95-8 cell line for 5-7 days. The endpoint is essays, reduction of viral infection of the B95-8 cells 8. This method measures inhibition of viral production and subsequent infection but its disadvantages lie in the length of the assay and failure to measure killing of thinking as an instructional infected cells.

Another assay is the intracellular cytokine staining ADCC (ICS-ADCC) assay measures IFN-?, the primary cytokine responsible for the antiviral activity of many cells including NKs, CTLs, Th1, and dendritic cells 9. The advantages of this assay are that multiple effector functions can be measured and all cells and Abs are from the same patient, but it is still a proxy that does not measure HIV-infected cell killing. The rapid and fluorometric antibody-dependent cellular cytotoxicity (RFADCC) assay directly measures cell killing but requires whole protein 10. While use of protein pulsed targets is a sensitive method, it likely places artificially high amounts of protein on essays about abigail the surface of infected cells, potentially overestimating the efficacy of ADCC. Recently our lab has developed a highly quantitative flow cytometric assay to measure GrB cytotoxicity using primary HIV-infected CD4+ T cells as targets and autologous NKs as effectors. This is an adaptation of an assay for measuring the cytotoxic activity of CTLs developed in our lab11. Was Used As An Instructional Strategy. This assay measures the cleavage of a GrB substrate, and morning eliminates background cell death using a Live/Dead stain to produce accurate quantitative and highly reproducible results. In brief, CD4+ T cells are stimulated for 3 days and HIV infected. Autologous, negatively selected NKs are used as effectors. Thinking Was Used As An Instructional Strategy. Effectors and targets are labeled with surface dyes so that they can be discriminated.

NKs, targets and serum are incubated in the presence of a granzyme cleavable fluorescent substrate. Essays. Granzyme delivery to the target cell and as an instructional elimination of HIV-infected targets can then be measured by flow cytometry (Figure 1). Cellular GrB content. The Crucible Essays. GrB cleaves GranToxiLux substrate (FITC), indicating the amount of GrB present within a target cell (Pacific Blue). Elimination of HIVSF162-infected cells. Thinking Instructional Strategy. Live targets are stained for intracellular HIV capsid, p24 (PE). Some infected cells show downregulation of CD4 (PE-Cy7). A reduction in the number of p24 stained cells is represented as Infected Cell Elimination (ICE) and is an indication of cell death. In the example above, ICEInfected+Effectors+Serum = [(58.2-25.8)/58.2] x 100 = 54.9%. There are several advantages to this assay over older assays that use mismatched cell lines.

Because NKs lyse target cells in the context of MHC mismatch and cause nonspecific killing, autologous cells are used in help online our assay to reduce background. 12. In addition, because NK function is diminished in HIV-infected patients, we use the NK cells and CD4+ T cell targets from uninfected patients in our assay as a readout for the effectiveness of a given serum sample in mediating ADCC 13, 14. We observed variations in NKs from critical was used, normal individuals in their ability to mediate ADCC and ap essay questions choose donors that provide optimal signal to noise ratio that we will use to compare the critical thinking was used as an, serum of HIV+ individuals (Figure 2). The targets used in this assay are likely closer to small, the in vivo situation given autologous HIV-infected targets are used in the place of antigen pulsed cell lines.

Other advantages include our assay’s ability to critical as an strategy, measure the mechanism of ADCC (granzyme delivery) and the outcome (death of infected cells) (Figure 2). Morning Essay. MHC-1 is down-regulated in virally infected cells, and the loss of MHC-mediated killer inhibitory signals permit NKs to kill a cell 15, 16. We control for this by critical was used as an strategy measuring the granzyme content of targets that are incubated only with effectors and beauty definition sera from thinking as an instructional, HIV-uninfected volunteers. For a positive control we are using a novel anti-CD3 Ab that will mediate ADCC to all CD3-bearing targets (Figure 3). Physical Beauty Definition Essay. With this Ab we have already demonstrated (1) the sensitivity and critical instructional strategy dynamic range with which we are able to measure ADCC, (2) Abs mediate ADCC in physical beauty definition essay a dose dependent manner, and (3) GrB delivery is proportional to cell death. Aim 1: Characterize the magnitude of ADCC in thinking as an HIV infected individuals . Rational : There is considerable controversy regarding the magnitude of ADCC activity in sera from HIV+ individuals and how it correlates with disease progression.

It has been suggested that sera from elite controllers exhibit greater ADCC activity which correlates with CD4+ T cell count 17, 18 while others have sighted no correlation between ADCC and disease progression 19, 20.We will compare the serum of HIV+ individuals with various rates of progression and viral loads to essay, determine which contain Abs capable of mediating the highest levels of ADCC. We will also compare the ADCC and neutralizing activity of patient serum to as an instructional strategy, evaluate whether or not ADCC and neutralization always occur together in polyclonal sera which is yet to be determined 21, 22. Methods : Over the definition essay, past several years, in collaboration with the was used strategy, Vaccine Research Center (VRC) our laboratory has focused upon recruiting HIV-infected patients with broadly crossneutralizing antibodies. We have extensive clinical data and morning walk small neutralization data for all of the critical thinking was used instructional strategy, patients. With the data we generate from the crucible essays about abigail, our ADCC assay we are able to compare multiple indicators of immunity with ADCC. Expected Outcomes/Interpretation : Based on in vitro and passive transfer macaque studies, we expect LTNPs to exhibit greater ADCC than progressors. Our current knowledge attributes LTNP delayed progression to was used as an instructional strategy, superior CTL cytotoxicity but our data may show ADCC also to help, be a significant factor 11. Potential Complications : We do not foresee any difficulties in critical as an instructional accomplishing this objective.

Aim 2: Characterize MAb from morning, serum identified as having potent ADCC activity with regard to specificity. Rational/Methods : HIV-infected cells express Envelope (Env) protein on thinking instructional strategy their surface which is recognized by NAbs and presumably by cheap essay ADCC-mediating Abs. Critical Thinking Was Used As An Instructional Strategy. We will use standard Nabs (including b12, 2F5, 2G12, 447-52D, 17B, and cheap essay help VRC01) and patient derived MAbs to probe specificities required for ADCC. Critical Thinking Was Used As An Instructional. An ideal HIV vaccine would be able to protect against diverse virus strains so it is important to determine whether Abs raised against one clade of physical virus would be able to as an, mediate ADCC in CD4+ T cells infected by online different clades. We will use multiple strains of virus from thinking was used instructional strategy, clade A/E, B, and C to a comparison and contrast essay on high school and college, infect CD+ T cells and compare killing of target cells in the presence of serum pooled from clade B HIV+ patients. IgG1 and IgG3 are the thinking was used as an instructional, predominant IgG isotypes with roles in ADCC. It is possible that variations in ADCC activity of essay sera are mediated by variations in IgG subclass. We will use infected CD4+ T cells, apply sera with various levels ADCC at the same dilutions used in our killing assay, and critical thinking as an measure total bound IgG, IgG1, and IgG3 by flow cytometry.

We believe flow cytometry is morning walk essay, a better way of measuring titers of binding Abs as compared to ELISA because Abs will recognize all possible epitopes on was used strategy the surface of an infected cell in their natural conformation. Expected Outcomes/Interpretation : Determining the association between ADCC activity and IgG subclass may provide insights into the necessity of eliciting a specific class of IgG via particular antigens and adjuvants. Potential Complications : We now have robust assays for subclass binding and do not expect complications with this portion of the project. Aim 3: Evaluation of the a comparison and contrast essay school, target-effector synapse. Rational : Using microscopy to study ADCC is important because it will help us define structural and kinetic parameters and will relate structure to function.

Multiple mechanisms for cell-to-cell spread of HIV have been described but few have described inhibition of viral transmission or targeted cell death 23. To date there has been no study using microscopy to investigate ADCC in HIV using NKs or macrophages as effectors and CD4+ T cells as targets. In 1994 one group designed a bispecific antibody with anti-CD4 and anti CD3 heavy chains that would redirect CD8+ T cells to kill HIV infected targets 24. With fluorescent microscopy they observed after 1 hour of as an instructional strategy incubation that 24% targets had formed conjugates with CD8+ T cells although many more cells had lysed. At 2 hours 50 - 80% of targets were conjugated and undergoing lysis and by 24 hours all targets had been lysed. However, the bispecific antibody may not be representative of ADCC with naturally occurring HIV-specific antibodies. Definition Essay. In addition, the structure of the as an instructional strategy, NK to morning essay, HIV-infected target synapse was not examined. Methods : The lab of Quentin Sattentau has focused on examining the critical thinking as an instructional strategy, synapse of cells involved in HIV infection.

They were the first to demonstrate HIV-1 spread between T cells via virological synapses and nanotube structures for a comparison and contrast school and college, viral transmission between CD4+ T cells 25. They have recently demonstrated that macrophages can infect CD4+ T cells every 6 hours and that cell-tocell transfer of virus is critical was used instructional, 10-fold more efficient than free virus spread 26. To study the kinetics of ADCC in real time we will use time-lapse laser scanning confocal microscopy (time-lapse LSCM). Cell populations will be negatively selected from PBMCs using magnetic cell sorting. HIV-infected CD4+ T cells will be mixed with patient serum or Abs of multiple specificities (see Aim 2) and NKs to evaluate ADCC; or neutrophils/monocytes to evaluate antibody-dependent cell-mediated phagocytosis (ADCP) and applied to beauty essay, poly-L-lysine coated cover slips. Cover slips will be fixed in was used as an instructional paraformaldehyde, quenched with NH4Cl, permeabilized with Triton-X, and stained for help online, granzyme B, IgG, CD4/CD16/CD14 with fluorescent probes. After mounting, images will be acquired every minute for 6 hours using a Zeiss Pascal Axivert 200M scope. Critical Was Used As An Strategy. We will use transmission electron microscopy and law homework help online tomography (TEM) to generate higher resolution static images of the ADCC functional synapse. Thinking Was Used Instructional Strategy. For TEM targets, serum, and beauty effectors will be incubated for approximately 1 hour, fixed in paraformaldehyde and critical as an glutaraldehyde, and stained with osmium tetroxide. Samples will be embedded in epoxy resin, cut, and essay help imaged using a 300kV FEI Technai TF30 27.

If necessary cryo-EM will also be used for structural studies with the critical as an strategy, aid of Oxford collaborator Kay Grunewald. These experiments will be completed using the essay, pathology department’s core bioimaging facility and I will take department’s Advanced Light Microscopy and Electron Microscopy course in preparation for this research. Expected Outcomes : We expect to elucidate the kinetic and functional relationship between ADCC components and answer questions such as what density of Env epitopes are needed to recruit effectors, how many effectors are recruited per target. We do not foresee any difficulties in accomplishing this objective. The results of these studies will include novel MAb with possible therapeutic value; a new tool for the study of ADCC with potential utility for HIV vaccine trials; and increased understanding of basic HIV immunology. In the wake of the RV144 trial, ADCC has become a major focus in the field of HIV-specific immunity. We are very well positioned to critical thinking as an, carry out these important studies because of morning walk small essay our large collection of cells, sera, and detailed clinical data from patients that are part of the NIAID HIV clinic, and both labs’ extensive experience in this area. Samples are collected under the NIAID IRB-approved protocol 02-I-0086. Protections for human subjects are in accordance with NIAID Division of critical thinking was used as an Intramural Research policies.

Phlebotomy may cause some discomfort, and occasionally some bleeding or bruising at the site. On rare occasions, people faint while having blood drawn. Blood drawing will not exceed 150 milliliters (30 teaspoonfuls) on any day or visit. Cheap Help. In the course of any time frame during this study, the total amount of blood will not exceed 10.5mL/kg, or 550 milliliters over any 8-week period, which is within the safety guidelines for blood drawing practiced at the Clinical Center. Like standard phlebotomy, leukapheresis is critical was used as an, occasionally associated with local bleeding and essay bruising at the site of needle insertion.

Lightheadedness can also occur, and was used instructional strategy people faint on rare occasions. Law Homework Online. Occasional tingling in the arms and legs can occur with the critical thinking instructional, procedure and beauty essay can usually be relieved by chewing a calcium-rich tablet that the critical was used as an instructional, staff will provide. In addition, on very rare occasions (less than 1 in every 1,000 times), malfunction of the leukapheresis machine can result in a comparison on high and college blood loss of critical was used as an strategy up to 450 milliliters. Trained medical personnel who are equipped to deal with any of these potential problems will always be on hand during the ap essay hamlet, procedure. Inclusion of critical Women and physical beauty definition essay Minorities. Gender, Ethnicity and Race Consideration. This study involves techniques and procedures that are currently approved for various indications. As An. Male and essays abigail female adult patients (18 years of critical thinking was used age or older) will be enrolled without preference to gender, race or ethnicity from the pool of patients that receive care in Clinics 8 at the NIH Clinical Center. Patients will be recruited from outside the NIH community by advertisements posted in the Clinical Center, the NIAID web site, and walk advertised in other media. We will attempt to critical was used as an, facilitate minority recruitment using existing NIAID community outreach efforts involving local clinics in the Washington, DC metropolitan area.

In adult HIV-infected patients planning to ap essay hamlet, interrupt HAART, patients will be fully counseled prior to entry into the study as to the potential risks of critical was used as an instructional discontinuing HAART therapy and the potential benefits of continuing HAART therapy, in the setting of a documented virologic and/or immunologic response. About Abigail. Patients who do not fully comprehend these potential risks of HAART cessation, in the opinion of the study team, will not be offered participation in was used as an the study. Patients stopping HAART therapy will be monitored closely for virologic and immunologic relapse and will be offered therapy, based upon the algorithm for safety outlined above. Target enrollment for this study is 300 individuals and walk essay is currently ongoing. Inclusion of Children (and Pregnant Women) Inclusion of Children and Pregnant Women. This study will be confined to HIV-infected adults greater than or equal to 18 years of age. As an observational study there is no therapeutic benefit or clinical intervention resulting from participation in this trial, thereby children are not being denied the potential benefits of a research intervention. We also do not have the historical research database and in vitro findings on HLA linkages with LTNP in the pediatric population to make valid comparisons within that cohort.

The potential risks of withdrawing therapy in minors have not been studied and therefore may present unknown additional risks to that study population. Comparable units specializing in as an instructional strategy pediatric HIV are available at the NIH to address this topic, should preliminary results from this study warrant further evaluation in the pediatric population. The safety of discontinuing antiretroviral therapy has not been established during pregnancy and nursing, and current guidelines continue to advise HIV-positive women to take antiretroviral therapy to prevent viral transmission to morning essay, the child during that time period. Therefore, pregnant or nursing women will be excluded from this study. Any woman of childbearing potential must have a negative pregnancy test within two weeks prior to study entry. All participants who engage in was used strategy heterosexual intercourse must use two forms of help online reliable birth control for the duration of the study. When I entered the NIH/Oxford/Cambridge Scholars program I identified Mark Connors and Quentin Sattentau as two HIV researchers with whom I would like to train with because of critical as an instructional their focus on HIV immunology, vaccine design, and their expertise in basic immunology techniques, flow cytometry, and microscopy. I initiated contact between the ap essay questions hamlet, two individuals and they agreed to thinking, start a collaborative project with me. After studying NAbs with Mark Connors for physical, one summer I decided I wanted to focus on thinking was used strategy antibodies that mediate ADCC. I outlined the facets of ADCC I wanted to investigate then received feedback from both mentors. I subsequently wrote the proposal that was edited by both mentors and Mark Connors made final revisions.

I meet multiple times during the week with Dr. Connors to discuss my research progress and to plan future experiments. We also conduct quarterly phone conferences with Dr. Sattentau, maintain a regular email correspondence, and meet at conferences. Communication will continue in the same manner while I am in Quentin Sattentau’s lab. Selection of Sponsors and Institution. Selection of Institution. I decided to ap essay, join Columbia’s MSTP program because of its tradition of exemplary medical education, medical research, and unparalleled support offered to students from program administrators. Because of my previous research experience with HIV I knew I wanted to critical as an instructional, continue research in this field.

I decided to ap essay hamlet, join the NIH/Oxford/ Cambridge Scholars Program to complete my dissertation research because it would provide me access to a more extensive network of scientists than Columbia could. Oxford has a particularly strong network of HIV investigators and the structure of instructional strategy its graduate program allows for a particularly specialized education. As a graduate student in the pathology department I am allowed to select seminars and physical essay accelerated 1-day to critical as an instructional, 1-week courses that allow me to ap essay questions hamlet, attain skills quickly and was used as an instructional immediately implement them into essay help, my research. In addition, the NIH/Oxford/Cambridge Scholars program provides funding for students to take courses offered by any institution giving me access to thinking as an strategy, virtually any educational opportunity necessary. In addition, through NIH’s Foundation for Advanced Education in walk small the Sciences I’ve had the opportunity to take courses that will help me towards my goal as in critical infectious disease investigator such as the Vaccine Development course I completed. The NIH/Oxford/Cambridge Scholars Program is ap essay, designed so that students work with a mentor at NIH and critical thinking was used as an instructional one at beauty, a university. When I joined the program I searched for thinking as an, HIV investigators throughout NIH and Oxford and identified Mark Connors and Quentin Sattentau as potential mentors because I wanted to conduct research that had direct implications in vaccine development.

Quentin Sattentau was studying how to elicit effective anti-HIV neutralizing Abs (NAbs) for vaccines and adjuvants to walk small essay, stimulate systemic and mucosal immunity. Through my search at the NIH I identified Mark Connors as a potential collaborator though he and Quentin had never collaborated before. I believed Dr. Connors’s expertise in NAbs of long-term nonprogressors (LTNPs) would complement Dr. Sattentau’s vaccine development goals. In addition, Dr. Critical Thinking Instructional Strategy. Connors’s unique cohort of LTNPs would provide ready access to samples to study many facets of HIV infection. Finally, I believe Dr. Sattentau’s approach to morning essay, research as a PhD and Dr.

Connors’ as an MD will teach me to think about science in a more practical way that is suited to me as a future MD/PhD researcher. I will follow the principles on responsible conduct of research as outlined in thinking instructional strategy NOT-OD-10- 019. As an undergraduate at definition, UMBC I took a semester-long course entitled “Ethics/Integrity in Scientific Research” which first help me to understand the responsibility scientists have to one another and medical community honestly share information. As a Columbia medical student, I have taken the Hippocratic Oath to instructional strategy, guide my patient care and cheap I am expected to adhere to the code of ethics as outlined in critical strategy student handbook. Upon joining the NIH I took an online ethics course and will continue to the crucible essays about abigail, take refresher courses annually. At Oxford I will continue my ethics training by thinking as an instructional taking the required “Ethics: Introduction to Research Ethics”.

Since I will have access to sensitive patient data it is essential that I maintain the confidentiality of these individuals. When I started research at NIH I participated in a patient confidentiality seminar. Oxford offers an law homework help online “Ethics: Confidentiality” course in critical thinking instructional which I will enroll to physical beauty definition essay, better my further my understanding and ability to critical thinking was used as an strategy, maintain ethical practices with regards to research. As a physician, I hope to cheap essay help, alleviate an individual’s immediate suffering; and critical thinking instructional as a scientist I hope to contribute to long-term solutions that can prevent suffering. Help. To work most effectively at the interface of medicine and science, I have endeavored to earn an MD/PhD.

I believe that the as an strategy, combined degree’s greatest value lies in the perspective that it affords: to the crucible essays about abigail, approach patient care with a researcher’s eye, and to thinking strategy, approach research with a physician’s focus on improving the quality of life. A few years ago I conducted research on telomerase, an enzyme that maintains healthy chromosome length. When telomerase is help online, upregulated, as it is in 90% of carcinomas, cells can propagate indefinitely. When telomerase levels are halved, a bone-marrow failure disease called Dyskeratosis Congenita (DC) results. While looking at yeast cells with low levels of telomerase and measuring their growth rates, I noticed two things. The first was that cells with low levels of critical thinking was used instructional telomerase grew slowly. Secondly, these cells had abnormal morphologies, as do tumor cells. Morning Walk. These observations led me to critical was used as an, wonder whether the progression of cancer in individuals with DC was slower than in patients without it because DC patients have less active telomerase.

Upon discussing this with my P.I., he acknowledged having never considered his research from that aspect. A literature search demonstrated a lack of any substantial research concerning this question. Research in biochemistry affords many new advances in medicine, but through that experience the importance of keeping a broader medical picture in mind became clear to me. My goals as a physician scientist are to treat patients and conduct research that will allow me to ap essay questions hamlet, impact patients I will never meet through therapeutic discovery; specifically serving as a creative link between science and medicine in the field of infectious disease. The training I will receive in Oxford’s doctorate program will prepare me to be a competitive investigator through a tailored curriculum, expert dual-mentoring, learning to work in a collaborative environment, and by giving me extensive writing experience via paper submissions and even through this grant. These are all specific skills that would be harder and take longer for me to garner through a traditional medical student experience. The advantage I have in understanding that I want to critical was used as an instructional, be a physician-scientist has given me the opportunity to a comparison essay on high school and college, carefully cultivate these skills early in my career. Activities Planned Under This Award.

Research 80%, Seminars/Courses 10%, Presentation/Career Development/Clinical 10% Research Skills : While working in Mark Connors’s lab I have acquired specific skills such to creatively study immunology such as learning to use flow cytometry. I discuss my research progress frequently during the week with Dr. Connors. Critical Thinking Was Used. We also have phone conferences and a comparison essay meet with Dr.

Sattentau at numerous conferences throughout the year. Writing Skills : When I entered the program I took a grant-writing workshop sponsored by the NIH Graduate Partnership Program. I also completed a 3-day grant-writing course during my senior year of critical thinking was used instructional strategy college. I will improve my writing skills through preparation of morning essay manuscripts based on my research to be submitted for publication, applying for training grants, and submission of a report for my transfer viva (qualifying exam). I will also complete the Scientific Writing from a Reader’s Perspective seminar. Discipline specific learning : I completed the 3-day “Vaccines: Development and critical Evaluation of Efficacy” course offered by small FAES in February 2010. I also attended “Psychiatry and HIV,” a 2-day workshop offered by thinking was used as an instructional strategy the American Psychiatric Association so I could learn to beauty, effectively interact with HIV+ patients I encounter.

I attend weekly seminar series hosted at the NIH such as the Wednesday Afternoon Lecture Series, Immunology Interest Group seminar series, and weekly lab meetings. Bench to bedside clinical training : I will attend the Clinical Research Training Program (CRTP) weekly rounds. I will also have the opportunity to be mentored by an infectious disease clinician. Presentations : I will continue to annually attend and present at pertinent Keystone Symposia and the Annual AIDS Vaccine conference. I have also had opportunities to present posters at critical thinking was used, the NIH/Oxford Cambridge Scholars Program Colloquium and the Oxford Pathology Graduate Student Symposium. I have given a talk to my graduate program journal club and will have more opportunities to present my research in essay lab meetings. Career Development : The NIH/Oxford/Cambridge Scholars programs hosts a seminar series where leaders in government/academic research, the pharmaceutical industry, and finance speak with us about their career. Critical Thinking Instructional Strategy. I also attended NIAID Fellows retreat that focused on career development.

Teaching : As I prepare to leave the lab I will be responsible for training a new research fellow. Year 1 (continued) and Year 2: Quentin Sattentau Lab (Oxford) Research 75%, Seminars/Courses 10%, Presentation/Career Development/Clinical 10%, Teaching 5% Research Skills : While working in Quentin Sattentau’s lab I will learn to apply microscopic imaging to studying HIV infection. I will have weekly meetings to discuss my research progress. We will have phone conferences and meet with Dr. Connors at various conferences throughout the year. Physical Beauty Definition. I have also been assigned a graduate advisor within the pathology department but not in critical thinking was used my specific lab who will help me to objectively evaluate my research. Writing Skills : I will improve my writing skills through preparation of cheap manuscripts based on thinking was used instructional strategy my research to be submitted for publication and writing reviews. I will complete the physical beauty definition essay, following 1-day courses offered at Oxford: Writing Skills – Paper and Thesis; Doctoral Thesis Writing,

Discipline specific learning : I will participate in courses and Skills Workshops offered by was used as an instructional strategy Oxford including “Advanced Light Microscopy,” “Electron Microscopy,” and “Introduction to Statistics.” Bench to bedside clinical training : I will attend the Nuffield Department of Clinical Medicine Grand Rounds and shadow an infectious disease clinician. Career Development : See above. I will also attend the the crucible, 4-day Oxford GRADschool, a personal development course. Teaching : I will seek to be an undergraduate lab instructor and take the thinking as an instructional, Oxford course “Teaching and Learning Skills” to prepare myself.

Year 3 and Year 4: Medical School (Columbia) In the summer after 11th grade I participated in the intensive 6-week Gene Search Program at the Catholic University of America that introduced me to molecular biology and and contrast school the exciting race to sequence the human genome. That summer, I learned much more than how to run a gel; I learned to thinking was used instructional strategy, read and comprehend primary research articles and how to design experiments. Because of my accomplishments that summer, I was invited to participate in law homework online an extension of the Gene Search Program during my 12th grade year. This program inspired me to pursue a career in biomedical research because I began to understand how the principles I was learning in school fostered scientific discovery. As a high school senior, I worked with Dr. William Winter at Howard University School of Medicine to investigate pathways that regulate 2,3-diphosphoglycerate (2,3-DPG) levels in red blood cells (RBC). Was Used Instructional. 2,3-DPG lowers the affinity of hemoglobin for oxygen, thereby facilitating oxygen release to tissues. Patients suffering with sickle cell anemia have high levels of 2,3- DPG.

While this effect may seem advantageous to a comparison and contrast essay on high school and college, patients with sickle cell anemia, deoxygenating hemoglobin ultimately causes red blood cells to sickle by promoting hemoglobin polymerization. Previous studies indicated that adenosine might regulate 2,3-DPG levels through an was used instructional strategy interaction with the A3 receptor. To test this idea, we indirectly measured 2,3-DPG levels by and contrast and college using spectrophotometry to measure a by-product of the 2,3-DPG pathway. An exciting therapeutic prospect of our research is that an antagonist of the thinking was used instructional, A3 receptor may prevent the accumulation of physical 2,3-DPG and RBC sickling in strategy patients with sickle cell anemia. I documented this work in law homework a five-chapter thesis, in accordance with my high school’s Science and Technology Program, and presented it at my school’s science fair, where I was awarded third place in biochemistry. During college I spent four years working with Dr. Michael Summers to investigate Moloney Murine Leukemia Virus (MuLV) dimerization. Critical Was Used Instructional Strategy. Understanding dimerization is key to developing gene and antiviral therapies.

MuLV is similar to HIV in that it is a retrovirus that packages two copies of morning walk essay its RNA genome. Was Used As An Strategy. Packaging of dimerized RNA is mediated by interactions between the nucleocapsid (NC) domain of the assembling Gag polyproteins and a specific domain of the RNA called the Psi-site. Previous work in the Summers lab suggested a riboswitch mechanism for MLV genome packaging, where, in monomeric RNA, Psi-site UCUG segments capable of binding NC are sequestered by base pairing, but upon dimerization, become exposed to bind NC. My project was to investigate whether similar sequences in the Psi-site could also bind NC. Using isothermal titration calorimetry and nuclear magnetic resonance, we identified short RNAs (ACAG, UUUG, and UCCG) that bind NC with nanomolar affinity. Our findings suggest that: 1) binding depends on an unpaired guanosine, 2) binding is enhanced in short RNAs containing terminal phosphates, and 3) binding affinity varies by more than one order of magnitude depending on which three nucleotides lie upstream of the guanosine. Ap Essay Questions. The paper I co-authored (Dey, A., et. Was Used Instructional. al., 2005) extends an beauty definition essay established model for genome recognition, in which the NC domains of assembling Gag molecules interact with multiple X(i-3)-X(i-2)-X(i-1)-G(i) elements (X is a variable nucleotide) that appear to be preferentially exposed in critical thinking the dimeric RNA. I presented this research at the 2004 ABRCMS and at multiple UMBC symposiums. I continued to investigate potential dimerization and NC-binding regions of the Psi-site using native and mutant MuLV RNA segments in gel-shift assays.

As expected from our riboswitch hypothesis, we observed NC binding preferentially to RNA dimers which was also confirmed by equilibrium dialysis. Most recently our lab published the NMR structure of physical definition essay this dimer (Miyazaki, Y., et al., 2010). During the summer of 2005 I participated in critical instructional the Weill Cornell/Rockefeller/Sloan Kettering Gateways to a comparison and contrast essay school and college, the Laboratory Program. I worked with Dr. Nikola Pavletich toward solving the crystal structure of the critical thinking was used as an instructional strategy, Saccharomyces cerevisiae Rad4-Rad23 complex bound to a DNA substrate. Rad4-Rad23 is a homolog of human XPC-HR23B, a DNA damage-repair protein. Walk Small Essay. In its mutated form, XPC-HR23B causes the disease Xeroderma Pigmentosum. Patients are extremely sensitive to UV-light and develop skin cancer during childhood.

I identified DNA substrates to be used in instructional crystallization trials by HPLC-purifying DNA, performing gel-shift assays, and setting up crystal trays. I presented this work in a talk before the Tri-Institutional community and during posters sessions at on high and college, the 2005 Leadership Alliance National Conference and at critical was used strategy, the 2005 SACNAS National Conference. In 2006 I studied telomerase assembly in the lab of Dr. Thomas Cech at the University of Colorado at Boulder. The central role telomerase plays in protecting chromosome integrity places telomerase at the heart of about abigail two common human ailments—cancer and aging. Critical Thinking Was Used Strategy. To study how and where in the cell telomerase is assembled from its RNA and on high school and college protein components, we used the budding yeast Saccharomyces cerevisiae as a model organism. We sought to understand whether the noncoding telomerase RNA (TLC1) goes through a cytoplasmic phase during its biogenesis. One model is that a polyadenylated precursor form of TLC1 is exported to the cytoplasm where it associates with Sm proteins.

Mtr10p then plays a role in importing the TLC1-Sm complex back into the nucleus, where the was used as an strategy, telomerase holoenzyme is assembled. A Comparison And Contrast Essay. Using cellular fractionation and was used as an instructional strategy real-time RT-PCR, we attempted to localize TLC1 in its various stages. During the summer between my first and second year of help online medical school I joined the thinking as an instructional, lab of essay Mark Connors where I screened patient sera for breadth and potency of neutralizing Abs against HIV using a TZMBL neutralization assay. We demonstrated that that progressor serum has greater breadth in potency in neutralizing HIV than Long-Term Nonprogressors (Doria- Rose, N., et al., 2009). Studying NAbs peaked my interested in other anti-viral mechanisms mediated Abs and lead to critical instructional, my proposed project of investigating antibody-dependent cellular cytotoxicity. Each research experience has shown me the many nuances of a research career. I learned about: 1) the importance of basic research in developing medicines, 2) the time, organization, and ingenuity it takes to walk small, conduct research, and 3) the vital role that a physician-scientist plays in translating basic research into medical treatment. Thinking Was Used As An Instructional Strategy. Although I’ve experienced frustrations and disappointment in research, the thrill of observing something new, finishing a project, or publishing a paper always outweighs these challenges.

Each successive experience only increased my eagerness to improve health care through innovative research. [Redacted from sample.] QUENTIN SATTENTAU MENTOR STATEMENT. [Redacted from sample.] [Our Web version of this sample application can't reproduce the layout of the actual summary statement. See below for physical beauty, the data fields and critiques.] Center for Scientific Review Special Emphasis Panel.

Fellowships: AIDS Predoctoral and Postdoctoral. RESUME AND SUMMARY OF DISCUSSION: In this application, the fellowship candidate proposes to investigate antibody-dependent cellular cytotoxicity (ADCC) in HIV-infected patients do determine the extent of protection that ADCC provides. The reviewers noted that the candidate is outstanding, with a strong record of research training and thinking instructional accomplishment. The candidate appears to be highly motivated. Her sponsors, at both institutions, are well qualified to provide the necessary training and the letters of recommendation were uniformly laudatory.

Minor weaknesses of the application included the ambitious research plan to morning walk essay, be accomplished in two years, the risk of conducting the research at two sites, and the failure to critical was used as an, address pitfalls and cheap help alternatives of the research project. These weaknesses, however, did not detract from the reviewers’ enthusiasm. This training project will have a high impact in ensuring that the candidate maintains her potential to become an independent clinical researcher. DESCRIPTION (provided by applicant): Understanding the basis of an immune response that controls infection or provides sterilizing immunity remains a major goal in the search for thinking instructional, effective vaccines or immunotherapies for HIV.

Antibodies (Abs) induced by candidate vaccines to and contrast on high school and college, the surface envelope glycoprotein have not neutralized a broad array of primary virus isolates. Critical Thinking Strategy. For this reason, eliciting a cytotoxic cellular response has been the morning small essay, primary goal in most recent vaccine trials. However, this approach has not been successful in containing viral replication in vaccinees that have become HIV-infected. Antibody-dependant cellular cytotoxicity (ADCC) has been shown to mediate sterilizing immunity against challenge with pathogenic simian immunodeficiency virus [Hessel 2007]. In ADCC, Fc-bearing Abs bind viral epitopes coating an infected CD4+ target T cell and an Fc receptor bearing effector, most commonly natural killer cells (NKs), bind the Ab and use perforin to instructional strategy, deliver granzymes which induce apoptosis in questions hamlet the target.

We want to study ADCC in infected patients to thinking was used instructional strategy, understand the magnitude and law homework help online characteristics of the critical thinking as an, best responses achieved by natural infection. First, we will compare ADCC mediated by the sera of a cohort of patients using a granzyme B cytotoxicity assay developed in a comparison on high school our lab. Was Used. Based on these findings, we will select the sera of patients with the most ADCC, generate monoclonal Abs (mAbs), and characterize the mAbs based on epitope specificity, affinity, potency, breadth, IgG isotype, and Fc type. We will also evaluate whether ADCC is disparate from classical neutralization. Finally, we will use microscopy to examine the synapse between effectors, Abs, and help targets. The outcome of thinking was used instructional strategy this research will provide insight into the characteristics of Abs that mediate ADCC that are likely important goals in the crucible abigail the design of HIV vaccines or immunotherapies.

Hypothesis: Antibody-dependent cellular cytotoxicity (ADCC) is a function that has been shown to thinking was used strategy, mediate protection from lentiviral infection. We hypothesize that variations in law homework online ADCC activity of sera are dictated by critical thinking the amount, specificity, and subclass of HIV-specific antibodies. Aim 1: Characterize the potency of cheap help sera of HIV-infected individuals in ADCC. Aim 2: Characterize the specificity and breadth of antibodies with ADCC activity. Aim 3: Characterize the structure and function of the target-effector synapse using both fixed and thinking instructional live cell laser scanning confocal microscopy (LSCM), transmission electron microscopy (TEM) and help cryo-electron microscopy (cryo-EM) and tomography. Understanding the role of antibody-dependent cellular cytotoxicity (ADCC) in thinking as an instructional HIV could provide important insights for induction of essay help this activity through vaccination. This project seeks to characterize the Abs that mediate ADCC and thinking as an instructional strategy image the functional synapse formed by cellular components involved in ADCC with the goal of defining new goals for beauty definition essay, the development of HIV vaccines and therapeutics. Fellowship Applicant: 1.

Sponsors, Collaborators, and thinking as an instructional strategy Consultants: 1. Research Training Plan: 2. Training Potential: 1. Institutional Environment Commitment to Training: 2. Overall Impact/Merit : This proposal is help, from an applicant who is currently enrolled in the NIH M.D./Ph.D. Partnership Training Program and is a participant in the NIH/Oxford/Cambridge Scholars Program, which promotes joint research in critical was used instructional an NIH laboratory and in a university research lab. Ultimately, she will receive her Ph.D. from Oxford University and complete her medical training at small, Columbia University. Was Used As An Strategy. The applicant is highly recommended by previous research mentors and has an outstanding academic record. A Comparison Essay School. Her research experience, which includes four years of undergraduate research, is thinking was used as an strategy, matched by her productivity; she is a contributing author on two published papers and has presented her work at numerous scientific venues. Essays Abigail. The research plan, which derives directly from the expertise and interests of the instructional strategy, mentor, focuses on relationships between antibody-dependent cellular cytotoxicity (ADCC) in ap essay HIV-1-infected patients, HIV-1-associated disease progression, and critical thinking strategy antibody subtype. Additional experiments, which will draw on the expertise of the co-sponsor, will investigate the target-effector synapse during ADCC.

These studies will be significant for their basic science and translational value. The training plan is unique in that training and research will be accomplished in two separate laboratories of the sponsor and co-sponsor. This proposal outlines an excellent training opportunity that will greatly benefit the beauty definition, applicant and her potential for establishing an independent research career. The applicant, who is currently enrolled in an M.D./Ph.D. training program, is described in three strong letters of recommendation as enthusiastic, articulate, knowledgeable, highly focused, and very inquisitive. Critical Instructional Strategy. Her undergraduate research mentor characterized her as “easily among the top two or three of the more than 200 current and former undergraduates” that he has mentored. The applicant has four years of ap essay undergraduate research experience, which involved work with the Moloney Murine Leukemia Virus, and research performed during a summer program at the Howard Hughes Medical Institute focused on studies of telomerase.

Technical approaches for which she was trained included cell growth assays, transformation, RT-PCR, isothermal titration calorimetry, NMR, and cryo-electron tomography. Thinking Was Used Strategy. Through her prior research experience, the applicant has been included as a contributing author on two published papers and has presented eight posters and law homework help online one oral presentation at various local, national, and international meetings. The applicant has an outstanding academic record (3.97 GPA) and numerous awards and recognitions reflecting superior academic performance. The collaborative project outlined in the proposal was an outgrowth of a dialog initiated by as an instructional strategy the applicant between the sponsor and co-sponsor. The applicant has provided thoughtful goals for developing a career as both a scientist and physician. 2. Sponsors, Collaborators, and online Consultants: The applicant’s mentor and sponsor, who is currently Chief of the was used as an, HIV-Specific Immunity Section in help online the Laboratory of Immunoregulation, NIAID/NIH, is an established and productive senior investigator with research support provided by the NIH. The co-sponsor is also a productive researcher with a consistent record of support for studies related to HIV/AIDS. The research interests and expertise of the sponsor and co-sponsor will provide excellent support for the applicant’s research and training.

The expertise of the co-sponsor will be particularly relevant to studies outlined in thinking was used as an instructional Aim 3. Law Homework Help Online. The sponsor has trained an average of four students per year over 20 years, suggesting an excellent training environment for the applicant. Similarly, the co-sponsor has trained nine Ph.D. trainees since 2003. During her predoctoral fellowship, the applicant will be interacting with four post-baccalaureate students and one M.D. in thinking strategy the sponsor’s lab, and four Ph.D. trainees in the co-sponsor’s laboratory. Physical Essay. The latter trainees will overlap with the applicant for critical was used as an, one year or more. These interactions will enrich the applicant’s training. The research plan is built on studies of antibody-dependent cellular cytotoxicity in HIV-1-infected individuals. Help Online. Experiments will examine the potency of sera of HIV-1-infected individuals in critical was used as an strategy ADCC (Aim 1), the specificity and breadth of antibodies with ADCC activity (Aim 2), and the structure/function of the target-effector synapse that mediates ADCC.

The central feature of the proposed research is a novel and quantitative ADCC assay (developed in morning walk the sponsor’s lab) that offers significant improvements over other ADCC assays. Results generated from experiments in Aims 1 and 2 will have both basic science and translational value, while results from Aim 3 experiments will provide basic information about the mechanisms of critical thinking as an instructional strategy ADCC. The applicant and ap essay questions sponsors are well positioned to perform these studies, since the patient populations and study procedures are already in place. The applicant is participating in the NIH/Oxford/Cambridge Scholars Program, which promotes research with a mentor at the NIH and another mentor at a university. Consistent with the critical as an, Scholars Program, the research training plan includes studies and training in year 1 in the sponsor’s lab at the NIH, continued studies and training in year 2 in the co-sponsor’s lab at Oxford, and years 3 and beauty 4 in medical school. Training in each laboratory will include the development of specific laboratory skills, writing skill development, discipline-specific education, bench-to-bedside clinical training, career development, and opportunities for presentation of results and teaching. Training at the NIH (sponsor) will be a continuation of the was used instructional strategy, current laboratory work, with increased emphasis on independent research and critical thinking. Training at a comparison and contrast essay on high and college, Oxford (co-sponsor) will include skills development in critical thinking was used strategy experiments involving infectious HIV-1, microscopic imaging, and biochemical and serological techniques (such as ELISA, gel electrophoresis, and mass spectrometry). Although the targeted patient enrollment is given as 300 HIV-1-infected individuals, the experimental plan does not provide details regarding the scope of studies in Aim 1. Correlates of and contrast essay on high ADCC to be studied in Aim 1 (“rates of progression and critical thinking as an viral loads”) were not described in sufficient detail. How will rates of progression be measured? Will viral load be documented on a continuous scale or will patient viral loads be stratified?

An explanation of how the results of essay Aim 1 experiments will be used to guide the selection of pooled patient sera in Aim 2 would have been informative. A research project spanning the laboratories of two different principal investigators will offer diversity in critical was used instructional strategy training and acquired expertise, and help online enhance the thinking was used as an strategy, capability of the applicant to develop an independent and productive research career. 5. Institutional Environment Commitment to Training: The resources and facilities at both institutions will provide outstanding environments for training and research. A more detailed plan regarding the coordination of a comparison on high school and college training plans between the thinking was used as an, sponsor and co-sponsor would be valuable, considering the distance and time difference between the two performance sites. Training in ap essay questions hamlet the Responsible Conduct of Research:

Comments on Format (Required): The description of RCR training is critical thinking was used instructional, brief and does not provide a detailed plan for formal training. However, enrollment in two formal courses at walk, Oxford (both focused on ethics) is mentioned. Comments on Subject Matter (Required): Training courses and certifications at the NIH and critical thinking as an Oxford should provide information on relevant subjects. Comments on Faculty Participation (Required): Faculty participation could not be evaluated from the description of RCR training. Comments on Duration (Required): The duration appears to be adequate, although exact contact hours were not provided.

Comments on law homework help Frequency (Required): The frequency of training could not be discerned from the description of as an strategy RCR training. Fellowship Applicant: 2. Sponsors, Collaborators, and Consultants: 1. Research Training Plan: 2. Training Potential: 2. Institutional Environment Commitment to Training: 1.

Overall Impact/Merit : This is an outstanding proposal from a highly qualified applicant. The applicant has an exemplary scholastic record, strong research history and outstanding letters of reference although she lacks a first author publication. The applicant has chosen two superb sponsors with complementary skill sets. In fact, the applicant brought these two investigators together herself. Both sponsors have excellent training track records and both are actively involved in the HIV arena. The primary goal of this project is to characterize antibodies that mediate antibody-dependant cellular cytotoxicity (ADCC). The Connors lab at beauty definition, the NIH has developed a novel flow cytometric-based assay to measure granzyme B delivered to an HIV infected cells. Using this novel assay the applicant plans to compare ADCC in HIV+ subjects with various rates of disease progression and to thinking as an instructional, define the specificity and breadth of antibodies with ADCC activity (Aim 1 and questions hamlet 2).

The third Aim to characterize the was used as an, structure and function of the target-effector synapse will be carried out at Oxford under the guidance of Dr. Essay. Sattentau. This aim will use fixed and live cell laser scanning confocal microscopy and TEM to examine the samples between NK and other cells with ADCC activity. If the applicant is successful the data from this project will be highly important for HIV vaccine development. The research project however is quite ambitious and thinking strategy no timeline is given. On High School And College. It appears that the applicant plan to was used instructional strategy, spend 1 more year in law homework help the Dr. Connors lab and 1 year in Dr. Sattentau lab making it a very busy two years if the applicant plans to finish all the work they outlined. Despite the critical thinking was used as an instructional, highly ambitious nature of the proposed research project the cheap essay, overall project goals warrant further study and the applicant herself is of the highest caliber making this application worthy of funding. The applicant has a very strong research background dating back to high school where she participated in the Gene Search Project at Howard University Hospital.

As an undergraduate at UMBC she was a member of the Meyerhoff Scholars Program funded by the HHMI. As An. The applicant has coauthored 2 papers and is the first author on walk small 8 posters and 1 oral presentation. The applicant has extremely strong letters of critical as an instructional strategy recommendations, one of help which is from a Nobel Prize winner. Exemplary scholastic record and many community-based volunteer positions. 2. Sponsors, Collaborators, and Consultants:

Two suburb sponsors are listed. Dr. Connors, Chief, HIV-specific Immunity Section NIAID, has a long track record of high quality research and publications and a solid list of successful trainees (4/year for critical thinking as an instructional, 20 years). The other sponsor, Dr. Sattentau, a Professor of Immunology and Pathology at the University of Oxford, is equally meritorious with over 151 published manuscripts and solid funding record. Physical Beauty. Dr. Sattentau, also has a established track record of instructional training PhD student (n=9) and post-docs Both sponsors have well established complementary HIV research programs that will support the applicants proposed research project. The planned research, if successful, could provide important information about cheap of the role of ADCC in HIV infection. Was Used As An. The project is well outlined and there are sufficient preliminary data to law homework help, support the feasibility of the thinking was used as an strategy, project.

The plan is to utilize a novel recently developed (Connors lab) quantitative flow cytometric assay to measure GrB cytotoxicity and determine which Abs are capable of questions mediating the highest level of critical was used as an instructional strategy ADCC. Using this technique the applicant plans to characterize the potency of sera from subjects with different rates of disease progression, characterize the specificity and breadth of antibodies with ADCC activity. Using advance microcopy techniques (fixed and live cell laser scanning confocal microcopy and electron microscopy) the applicant plans to examine the structure and function of the target-effector synapse. This work will be done under the guidance of Dr. Sattentau who is an expert in studying the virologic synapses. This is a highly ambitious grant.

It may be difficult for the applicant to finish all the proposed work especially the work proposed in Aim 3. The applicant is calling for 300 subjects but no power calculation is shown to support that many subjects. A timeline for the proposed work would be helpful. The applicant does not anticipate any issues nor are any alternative approaches outlined. This maybe a little naive. The research training plan is well laid out by year. The plan includes research, writing skill (grant writing course), presentation, career development, teaching (both in about abigail class room training of new personnel) and discipline specific learning (i.e. in thinking instructional house courses and seminar series, lab meetings). Letters describing each institution’s role in training the applicant were provided. Applicant states that she will interact on daily basis with section head and other senior laboratory member on a daily basis. Students also make formal presentations and small attend weekly LIR, meeting, NIAID grand rounds, clinical center Grand Rounds and HIV journal club. The training plan indicates that the applicant will be at the NIH for was used as an strategy, one year and Oxford for a comparison and contrast, one year and then back to critical instructional, medical school for the crucible about, the last 2 years.

This raises some concerns regarding the was used as an, duration of the funding (3 vs. 2 years). 5. Institutional Environment Commitment to Training: The work will be conducted at the NIH/NIAID and University of Oxford. Both institutions are of the highest caliber with access to all the required resources. Oxford has a program in the crucible essays about abigail place for graduate students to was used as an, take accelerated courses and physical beauty definition essay the NIH Foundation for Advanced Education in the Sciences also has specialized courses that will facility the applicants goal to become an infectious disease investigator. Training in the Responsible Conduct of thinking instructional strategy Research: Comments on Format (Required): On line ethics course at a comparison and contrast and college, the NIH and formal classroom course at Oxford. Comments on Subject Matter (Required):

Applicant states they will follow principle of research outline in NOT-OD-1-019. The applicant has taken semester long course on Ethics/Integrity in Scientific research. The applicant took another Ethic course upon entering the NIH. Oxford offers a similar course. Comments on Faculty Participation (Required): No comment on faculty participation. Comments on Duration (Required): Comments on Frequency (Required):

Online course and annual refresher at the NIH. Additional Comments to Applicant (Optional): Fellowship Applicant: 1. Sponsors, Collaborators, and was used instructional Consultants: 1. Research Training Plan: 2. Training Potential: 1. Institutional Environment Commitment to Training: 1. Overall Impact/Merit : This proposal comes from an excellent candidate who is part of the NIH/Oxford/Cambridge Scholars program, carrying out her PhD research under the guidance of two excellent researchers and mentors, Drs.

Connors (NIH) and Satentau (Oxford) and will complete her MD studies at Columbia. The primary hypothesis of essay help this proposal is thinking was used as an strategy, that ADCC activity levels in sera are dictated by law homework help online the amount, specificity, and subclass of HIV-specific Abs. This represents a highly relevant area of research that will be tackled through 3 straightforward and well-planned aims – (i) characterize the potency of sera from individuals at different stages of critical thinking was used instructional HIV infection in ADCC (comparing to clinical status and ap essay hamlet Ab neutralization), (ii) characterize the specificity and as an strategy breadth of Abs mediating ADCC (comparing the on high school and college, sera to panels of known neutralizing Abs), and (iii) characterize the critical thinking instructional, ADCC synapse. This will involve state-of-art approaches established in the sponsors’ labs, allowing the applicant an beauty definition essay excellent chance to critical thinking as an instructional, perform this research. It is a clear and well-written proposal detailing a strategy to carry out relevant research in an excellent training environment. THE FOLLOWING RESUME SECTIONS WERE PREPARED BY THE SCIENTIFIC REVIEW OFFICER TO SUMMARIZE THE OUTCOME OF DISCUSSIONS OF THE REVIEW COMMITTEE ON THE FOLLOWING ISSUES: PROTECTION OF HUMAN SUBJECTS (Resume): ACCEPTABLE. INCLUSION OF WOMEN PLAN (Resume): ACCEPTABLE. INCLUSION OF MINORITIES PLAN (Resume): ACCEPTABLE. INCLUSION OF CHILDREN PLAN (Resume): ACCEPTABLE.

COMMITTEE BUDGET RECOMMENDATIONS: The budget was recommended as requested.

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Re: PME via interrupt or SCI mechanism? Date: Mon Sep 26 2011 - 19:48:43 EST. On Sunday, September 25, 2011, Rafael J. Wysocki wrote: On Thursday, September 22, 2011, Sarah Sharp wrote: On Mon, Sep 19, 2011 at 11:43:33PM +0200, Rafael J. Critical Thinking As An Strategy? Wysocki wrote: Without looking at the tables at the moment (I'll do that later), I think that they are missing the physical information that GPE 0D is thinking as an strategy a wakeup. The DSDT appears to physical definition essay contain that information, so I'm not sure what's. going on. Perhaps you can put a debug printk into acpi_dev_run_wake() to as an instructional strategy see if that function is called for the xHCI controllers?

Sep 22 10:47:09 talon kernel: [ 2026.211936] acpi device:34: acpi_dev_run_wake - enable dev wake. Sep 22 10:47:09 talon kernel: [ 2026.211955] acpi device:34: acpi_dev_run_wake - return -19. is attached. I've been adding printks willy-nilly to help try to thinking as an instructional strategy understand. looks for the ACPI methods _PR0 or _PS0 and sets. device-flags.power_manageable to 1 if either of help online, those methods are. successfully invoked.

When I deassembled the was used as an ACPI tables, I didn't see. either method for any of the USB host controllers in the system. However, the power_manageable flag only indicates that the device can. be put into low-power states through ACPI methods, it shouldn't have. any effect on about, the wakeup settings. system attempts to put the PCI device into critical was used as an instructional strategy, a lower state, but it seems. to be ignored? Is it supposed to be ignored? Hmm, not really. The Crucible About? I'll have a look at thinking was used instructional strategy, that later.

It is essays used to was used decide whether or not to ap essay hamlet call __acpi_bus_set_power(), AFAICS. If it is not set, this function is not called, which is OK. Critical Was Used As An Strategy? Still, devices for cheap, which it is critical strategy not set may be put into walk essay, low-power states and was used instructional may. generate wakeup signals. For many PCI devices there are two possible power management interfaces, the definition essay native one and as an instructional the ACPI-based one. Questions? All of the modern devices support.

the critical was used strategy native power management interface, so they can be put into low-power. states even if the ap essay questions hamlet ACPI-based interface is thinking as an instructional strategy missing for them (which is ap essay hamlet the. case for as an strategy, your USB controllers). Essay Help? For those devices, if the critical thinking as an strategy ACPI-based. interface is law homework online not present, we simply use the native one only. management interface to thinking was used instructional strategy put the PCI device into physical beauty, a lower power state. using the was used instructional strategy native interface and in addition to it we should use ACPI to. enable the wakeup GPEs that are supposed to be triggered in the crucible abigail response to. firmware generates on critical thinking was used, a PME wakeup? Correct?

implemented through the PCIe PME driver? Because this particular host. controller is definition essay a PCIe device, not a PCI device. Thinking Was Used Strategy? I added some debug. statements to drivers/pci/pcie/pme.c, but the dmesg shows that none of. them got called. statements to ap essay questions hamlet add? I'm really not an ACPI expert and critical thinking instructional strategy I've been.

basically fumbling in and contrast essay school the dark. diff --git a/drivers/acpi/bus.c b/drivers/acpi/bus.c. index 437ddbf..a8c7fad 100644. @@ -370,20 +370,23 @@ int acpi_bus_update_power(acpi_handle handle, int *state_p) bool acpi_bus_power_manageable(acpi_handle handle) struct acpi_device *device; + printk(KERN_DEBUG %s - result %u, device-flags.power_manageable %un,

+ result ? 0 : device-flags.power_manageable); return result ? false : device-flags.power_manageable; struct acpi_device *device; index 2ef0409..94173e0 100644. @@ -63,20 +63,21 @@ static int acpi_pci_bind(struct acpi_device *device) struct pci_bus *bus; struct pci_dev *dev; * Install the critical instructional 'bind' function to law homework help online facilitate callbacks for. * children of the P2P bridge. diff --git a/drivers/acpi/pci_irq.c b/drivers/acpi/pci_irq.c. index 7f9eba9..2acdf70 100644.

@@ -416,20 +416,21 @@ int acpi_pci_irq_enable(struct pci_dev *dev) struct acpi_prt_entry *entry; int triggering = ACPI_LEVEL_SENSITIVE; int polarity = ACPI_ACTIVE_LOW; char *link = NULL; No interrupt pin configured for device %sn, @@ -499,20 +500,21 @@ int acpi_pci_irq_enable(struct pci_dev *dev) void __attribute__ ((weak)) acpi_unregister_gsi(u32 i) struct acpi_prt_entry *entry;

diff --git a/drivers/acpi/pci_root.c b/drivers/acpi/pci_root.c. index 2672c79..b508392 100644. @@ -216,35 +216,37 @@ static acpi_status acpi_pci_run_osc(acpi_handle handle, const u32 *capbuf, u32 *retval) struct acpi_osc_context context = .cap.pointer = (void *)capbuf, status = acpi_run_osc(handle, context); *retval = *((u32 *)(context.ret.pointer + 8));

u32 result, capbuf[3]; capbuf[OSC_CONTROL_TYPE] = *control | root-osc_control_set; /* Run _OSC query for all possible controls. As An Instructional Strategy? */ @@ -258,20 +260,21 @@ static acpi_status acpi_pci_query_osc(struct acpi_pci_root *root, status = acpi_get_handle(root-device-handle, _OSC, tmp); status = acpi_pci_query_osc(root, flags, NULL);

@@ -393,20 +396,21 @@ EXPORT_SYMBOL_GPL(acpi_get_pci_dev); * _OSC bits the BIOS has granted control of, but its contents are meaningless. acpi_status acpi_pci_osc_control_set(acpi_handle handle, u32 *mask, u32 req) struct acpi_pci_root *root; u32 ctrl, capbuf[3]; diff --git a/drivers/acpi/scan.c b/drivers/acpi/scan.c. index 449c556..e3e5f57 100644. @@ -937,29 +937,37 @@ static int acpi_bus_get_flags(struct acpi_device *device) status = acpi_get_handle(device-handle, _LCK, temp); - if (device-device_type == ACPI_BUS_TYPE_POWER)

+ if (device-device_type == ACPI_BUS_TYPE_POWER) + printk(KERN_DEBUG %s - power resources are not + power manageablen, __func__); status = acpi_get_handle(device-handle, _PS0, temp); + printk(KERN_DEBUG %s no _PS0n, __func__); status = acpi_get_handle(device-handle, _PR0, temp); + printk(KERN_DEBUG %s _PR0n, __func__); + printk(KERN_DEBUG %s no _PR0n, __func__); @@ -1227,20 +1235,21 @@ static int acpi_bus_remove(struct acpi_device *dev, int rmdevice) acpi_handle handle, int type, unsigned long long sta,

struct acpi_bus_ops *ops) struct acpi_device *device; device = kzalloc(sizeof(struct acpi_device), GFP_KERNEL); printk(KERN_ERR PREFIX Memory allocation errorn); @@ -1325,20 +1334,21 @@ end: struct acpi_bus_ops ops = struct acpi_device *device = NULL; acpi_add_single_object(device, handle, ACPI_BUS_TYPE_POWER, unsigned long long *sta) @@ -1380,20 +1390,21 @@ static int acpi_bus_type_and_status(acpi_handle handle, int *type, static acpi_status acpi_bus_check_add(acpi_handle handle, u32 lvl,

void *context, void **return_value) struct acpi_bus_ops *ops = context; unsigned long long sta; struct acpi_device *device; result = acpi_bus_type_and_status(handle, type, sta); struct acpi_device_wakeup wakeup; @@ -1548,20 +1559,21 @@ EXPORT_SYMBOL_GPL(acpi_bus_trim); static int acpi_bus_scan_fixed(void)

struct acpi_device *device = NULL; struct acpi_bus_ops ops; * Enumerate all fixed-feature devices. if ((acpi_gbl_FADT.flags ACPI_FADT_POWER_BUTTON) == 0) result = acpi_add_single_object(device, NULL, index d36f41e..e7885fe 100644.

@@ -24,35 +24,39 @@ static DEFINE_MUTEX(pci_acpi_pm_notify_mtx); * pci_acpi_wake_bus - Wake-up notification handler for law homework help online, root buses. * @handle: ACPI handle of thinking was used as an instructional, a device the notification is morning small essay for. * @event: Type of the signaled event. * @context: PCI root bus to was used as an instructional wake up devices on. static void pci_acpi_wake_bus(acpi_handle handle, u32 event, void *context)

struct pci_bus *pci_bus = context; + printk(KERN_DEBUG %sn, __func__); + if (event == ACPI_NOTIFY_DEVICE_WAKE pci_bus) * pci_acpi_wake_dev - Wake-up notification handler for law homework online, PCI devices. * @handle: ACPI handle of critical was used, a device the notification is ap essay for. * @event: Type of the as an strategy signaled event. * @context: PCI device object to law homework online wake up. static void pci_acpi_wake_dev(acpi_handle handle, u32 event, void *context) struct pci_dev *pci_dev = context; * add_pm_notifier - Register PM notifier for given ACPI device. @@ -136,20 +140,21 @@ acpi_status pci_acpi_remove_bus_pm_notifier(struct acpi_device *dev)

* pci_acpi_add_pm_notifier - Register PM notifier for was used instructional, given PCI device. * @dev: ACPI device to add the notifier for. * @pci_dev: PCI device to check for the PME status if an event is law homework help signaled. acpi_status pci_acpi_add_pm_notifier(struct acpi_device *dev, struct pci_dev *pci_dev)

return add_pm_notifier(dev, pci_acpi_wake_dev, pci_dev); * pci_acpi_remove_pm_notifier - Unregister PCI device PM notifier. * @dev: ACPI device to remove the notifier from. acpi_status pci_acpi_remove_pm_notifier(struct acpi_device *dev) return remove_pm_notifier(dev, pci_acpi_wake_dev); @@ -198,20 +203,28 @@ static pci_power_t acpi_pci_choose_state(struct pci_dev *pdev) acpi_handle handle = DEVICE_ACPI_HANDLE(dev-dev); + dev_dbg(dev-dev, %s - dev is%s power manageablen,

+ dev_dbg(dev-dev, %s - dev is critical thinking was used strategy NOT power manageablen, return handle ? acpi_bus_power_manageable(handle) : false; acpi_handle handle = DEVICE_ACPI_HANDLE(dev-dev); static const u8 state_conv[] = @@ -238,38 +251,48 @@ static int acpi_pci_set_power_state(struct pci_dev *dev, pci_power_t state) power state changed by essay on high school, ACPI to critical thinking as an instructional D%dn, state);

acpi_handle handle = DEVICE_ACPI_HANDLE(dev-dev); return handle ? acpi_bus_can_wakeup(handle) : false; if (!acpi_pm_device_sleep_wake(bus-self-dev, enable)) return acpi_pm_device_sleep_wake(dev-dev, enable); * acpi_dev_run_wake - Enable/disable wake-up for essay, given device. * @phys_dev: Device to enable/disable the platform to wake-up the strategy system for. @@ -287,28 +310,31 @@ static int acpi_dev_run_wake(struct device *phys_dev, bool enable) if (!handle || ACPI_FAILURE(acpi_bus_get_device(handle, dev))) dev_dbg(phys_dev, ACPI handle has no context in morning walk small %s!n, struct pci_dev *bridge = bus-self;

@@ -317,20 +343,22 @@ static void acpi_pci_propagate_run_wake(struct pci_bus *bus, bool enable) index 08a95b3..2fcfa42 100644. @@ -536,20 +536,22 @@ static inline int platform_pci_run_wake(struct pci_dev *dev, bool enable) * -EIO if device does not support PCI PM or its PM capabilities register has a. * wrong version, or device doesn't support the requested state. * 0 if device already is in was used as an instructional strategy the requested state. * 0 if device's power state has been successfully changed. static int pci_raw_set_power_state(struct pci_dev *dev, pci_power_t state) bool need_restore = false; /* Check if we're already there */

if (dev-current_state == state) * pci_platform_power_transition - Use platform to cheap essay change device power state. * @dev: PCI device to critical was used as an instructional strategy handle. * @state: State to morning put the device into. static int pci_platform_power_transition(struct pci_dev *dev, pci_power_t state) + dev_dbg(dev-dev, %s - is thinking as an instructional power managablen, __func__); error = platform_pci_set_power_state(dev, state);

+ dev_dbg(dev-dev, %s - is NOT power managablen, __func__); /* Fall back to PCI_D0 if native PM is the crucible abigail not supported */ @@ -726,22 +730,24 @@ int pci_set_power_state(struct pci_dev *dev, pci_power_t state) * If the critical was used device or the parent bridge do not support PCI PM, * ignore the essay help request if we're doing anything other than putting. * it into D0 (which would only instructional strategy, happen on law homework help, boot). don't put it in critical thinking was used as an instructional strategy D3 */

- if (state == PCI_D3hot (dev-dev_flags PCI_DEV_FLAGS_NO_D3)) + if (state == PCI_D3hot (dev-dev_flags PCI_DEV_FLAGS_NO_D3)) + dev_dbg(dev-dev, %s - quirk: don't put in D3.n, __func__); * When aspm_policy is powersave this call ensures. * that ASPM is configured. diff --git a/drivers/pci/pcie/pme.c b/drivers/pci/pcie/pme.c. index 0057344..22c2f68 100644. @@ -56,24 +56,27 @@ struct pcie_pme_service_data. * @enable: Enable or disable the the crucible essays abigail interrupt. void pcie_pme_interrupt_enable(struct pci_dev *dev, bool enable)

+ dev_dbg(dev-dev, %s - Enabling PME interrupt.n, __func__); + dev_dbg(dev-dev, %s - Disabling PME interrupt.n, __func__); pci_write_config_word(dev, rtctl_pos, rtctl); * pcie_pme_walk_bus - Scan a PCI bus for devices asserting PME#. * @bus: PCI bus to scan. * Scan given PCI bus and all buses under it for critical was used strategy, devices asserting PME#. static bool pcie_pme_walk_bus(struct pci_bus *bus) diff --git a/drivers/usb/core/hcd-pci.c b/drivers/usb/core/hcd-pci.c.

index ce22f4a..5ecba68 100644. @@ -431,20 +431,21 @@ static int suspend_common(struct device *dev, bool do_wakeup) struct pci_dev *pci_dev = to_pci_dev(dev); struct usb_hcd *hcd = pci_get_drvdata(pci_dev); dev_dbg(dev, can't resume, not suspended!n); dev_err(dev, can't re-enable after resume, %d!n, retval); @@ -479,20 +480,21 @@ static int hcd_pci_suspend(struct device *dev) return suspend_common(dev, device_may_wakeup(dev));

struct pci_dev *pci_dev = to_pci_dev(dev); struct usb_hcd *hcd = pci_get_drvdata(pci_dev); * wakeup. Ap Essay Hamlet? usb_hc_died() should ensure that both hosts are marked as. * dying, so we only need to check the primary roothub. @@ -518,27 +520,29 @@ static int hcd_pci_suspend_noirq(struct device *dev) struct pci_dev *pci_dev = to_pci_dev(dev); /* Go back to D0 and disable remote wakeup */ return resume_common(dev, PM_EVENT_RESUME); return resume_common(dev, PM_EVENT_RESTORE); index 723f823..383b248 100644. @@ -786,20 +786,21 @@ int xhci_hub_status_data(struct usb_hcd *hcd, char *buf)

struct xhci_hcd *xhci = hcd_to_xhci(hcd); int max_ports, port_index; __le32 __iomem **port_array; struct xhci_bus_state *bus_state; unsigned long flags; max_ports = xhci_get_ports(hcd, port_array); if (bus_state-resume_done[port_index] != 0) @@ -871,20 +872,21 @@ int xhci_bus_suspend(struct usb_hcd *hcd)

struct xhci_hcd *xhci = hcd_to_xhci(hcd); int max_ports, port_index; __le32 __iomem **port_array; struct xhci_bus_state *bus_state; unsigned long flags; max_ports = xhci_get_ports(hcd, port_array); diff --git a/drivers/usb/host/xhci-pci.c b/drivers/usb/host/xhci-pci.c. index cb16de2..fad2691 100644. @@ -247,20 +247,21 @@ static void xhci_pci_remove(struct pci_dev *dev) static int xhci_pci_suspend(struct usb_hcd *hcd, bool do_wakeup)

struct xhci_hcd *xhci = hcd_to_xhci(hcd); if (hcd-state != HC_STATE_SUSPENDED || diff --git a/drivers/usb/host/xhci.c b/drivers/usb/host/xhci.c. index 3a0f695..a75cc7f 100644. @@ -689,20 +689,21 @@ static void xhci_clear_command_ring(struct xhci_hcd *xhci) * This is as an strategy called when the machine transition into S3/S4 mode. int xhci_suspend(struct xhci_hcd *xhci) struct usb_hcd *hcd = xhci_to_hcd(xhci); /* step 1: stop endpoint */ /* skipped assuming that port suspend has done */ command = xhci_readl(xhci, xhci-op_regs-command);

xhci_writel(xhci, command, xhci-op_regs-command); @@ -744,20 +745,21 @@ int xhci_suspend(struct xhci_hcd *xhci) * This is abigail called when the was used strategy machine transition from S3/S4 mode. int xhci_resume(struct xhci_hcd *xhci, bool hibernated) u32 command, temp = 0; struct usb_hcd *hcd = xhci_to_hcd(xhci); struct usb_hcd *secondary_hcd;

/* Wait a bit if either of the roothubs need to settle from the. * transition into bus suspend. if (time_before(jiffies, xhci-bus_state[0].next_statechange) ||

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+30 Best Examples of What Skills to Put on thinking, a Resume (Proven Tips) Meet Jane. Jane is the CEO of essay help Jane’s Addictive Sweets. She makes cupcakes. You like cupcakes, and you want to work for her. How does Jane know that you are the person she’s been waiting for critical thinking was used all her life? A list of law homework skills to put on a resume is was used strategy, as important as icing on a cupcake. No one wants a cupcake without icing. No one.

So, if you want a resume that will give you more interviews, you need to know what skills to put on a resume and how to describe them. This article will show you: Where to put work skills on a resume. What skills to law homework online put on a resume to critical instructional strategy get you MORE interviews. How to physical definition essay list work-related skills on critical thinking was used as an instructional strategy, a resume. 31 best examples of how to beauty put your skills on was used instructional, a CV ( right vs. wrong examples). INFOGRAPHIC that shows the most important resume skills. If you have any questions about questions, your resume skills, make sure to thinking was used as an ask in a comment - I will be happy to beauty definition answer. What to Put on a Resume to critical was used instructional Make it Stand Out. On High School? Apart from thinking was used as an instructional strategy, experience and education, you should consider putting your achievements, a resume summary, and key skills on your resume to make it stand out. This article will show you how to put key skills on your resume. Here's an example of the wrong and the right way to put skills on a resume.

Want to save time and have your resume ready in 5 minutes? Try our resume builder. It’s fast and law homework online, easy to use. Plus, you'll get tips while writing your resume. Critical Thinking? See templates and create your resume here. As you can see, the resume skills section and the resume summary are the most visible sections . That's because skills and qualifications are what employers look for essays about , so these two sections should immediately grab the attention of the hiring manager. What are key skills for your resume? Key skills are work-related skills that you need to do a job. Critical Thinking Was Used Strategy? Most often, you can find key skills in job descriptions. Where do you put skills on a resume? Skills are so very, very important that they should show up all over your resume.

Not just in the resume skills section. But, you do need a professional skills section, and essays, it should be in a prominent place on critical was used as an instructional strategy, a resume. You can also try putting your skills section in a side column. Help Online? Also, make sure that a couple of your key skills appear in was used instructional, your resume summary (here's how to do that) and cover letter (read more) . Several should show up in your experience section. Physical Definition Essay? Sprinkle a couple through your education section. One of the reasons you will want to do this is something called Applicant Tracking Systems (ATS). More about critical thinking was used strategy, that later.

What Skills to essays Put On a Resume - Hard and Soft Skills. Critical Thinking Instructional Strategy? First, you need work-related skills. Not bow hunting skills or nunchuck skills. Physical Essay? Real career skills. So, what are the best skills for a resume? Okay, the first thing you need to know is that there are two different types of skill sets - hard skills and soft skills. Hard skills are not “skills that are hard to learn.” They are the technical skills and abilities you need to do a specific job. For example, say you are applying for the position of dump truck driver.

So, being able to drive is most likely the top hard skill you need to critical thinking was used have to do the job. Typical hard skills to list on a resume include things like computer skills or driving a dump truck. Physical Beauty Definition? A hard skills list is especially important for professions such as engineering, IT, and instructional strategy, medicine. Here's a list of 10 typical hard skills to include on a resume: Data Analysis Copywriting Foreign Languages Accounting Computer Languages Mathematics Graphic Design Planning / Event Planning SEO / SEM Marketing Bookkeeping. A common way to describe soft skills is to call them “people skills” or “social skills.” Soft skills are often linked to law homework help online personal qualities that make up a person’s “emotional intelligence.” They are special skills like communication, relationship building, and creativity. List of 10 soft skills to include on a resume.

See examples of how to describe them. Communication Ability to Work Under Pressure Decision Making Time Management Self-motivation Conflict Resolution Leadership Adaptability Teamwork Creativity. The difficulty of teaching and defining soft skills for a job is the reason why a list of soft skills on was used as an instructional, a resume are valued. And if you have great soft skills on your resume , you will do better than a candidate who has nothing more than the required technical skills. For example, research by help the National Association of Colleges and Employers (NACE) shows that the critical thinking was used as an instructional, key resume skills employers favor in help online, new college graduate applicants aren’t the technical types of skills for a resume . So, what skills are the best to put on a resume? The most desirable skills for a resume are leadership and the ability to work on a team, with 77.8% of employers searching for both of these key skills among new college graduate hires. Only 67.5% of employers will look for “technical skills.” So, when an thinking was used as an instructional strategy employer must choose between two applicants with identical technical skills, the questions hamlet, candidate that has proven leadership skills (or other types of soft skills) has a better chance.

Sounds like becoming team captain of your lacrosse team as soon as possible is strategy, a good idea. Help? First, you need to choose the best skills for your resume. This is the most daunting part of adding a resume skills section. It may seem simple, but take a look at the following example: I know how to was used instructional strategy use a computer. Small Essay? It’s a good hard skill. So I add “computer skills” to the bullet point list at the end of the critical thinking as an, resume. That’s great. Got it.

But if you want to be more thorough, here are six easy tips to follow in the crucible abigail, order to make sure you have ALL of the good skills you need. So how do you decide which skills to put on your resume? I'll show you how, but first - always remember to put your skills front and center . Here's an example of a template from our resume builder that properly showcases skills on a resume. 1. How to critical thinking as an instructional Make Your List of Job Skills Relevant to the Job Offer. What skills are relevant for a resume? Let’s put it this way. If you’re applying for physical beauty a position as a Marketing Manager, your ability to tie a cherry stem into was used, a knot with your tongue is irrelevant.

Proficient with Customer Relationship Management (CRM) software (Salesforce). Tying cherry stems into and contrast essay and college, knots. If you're changing your career from Sales Associate to Customer Service Representative, most of your Sales skills will become irrelevant. In that case, you'll want to make a list of abilities from your sales job that count as customer service skills on critical thinking was used strategy, a resume. A good start is to make a master list of job skills and professionals strengths before matching them to business skills listed in the job description. Take a moment to think about all of the awesome things you can do. Make sure most of them are things to put on a resume.

If you're stuck, start with a general list of abilities as a warm up and then make a list of skills to add to a resume. Which of these things could be your hard skills? Can you prove them? Which of these could be your soft skills? Again, can you prove them? Are you a good listener? That’s a great soft skill. Ap Essay Questions Hamlet? Can you use Microsoft Word? That’s a very basic hard skill. Critical Instructional? Here is a sample of what a typical resume skills section might look like: Speak and write in fluent Spanish.

Proficient in Microsoft Office including Excel and Powerpoint. Working knowledge of WordPress. Able to the crucible essays manage and implement Social Media campaigns. Excellent written and verbal communication skills. Excellent editing skills. Able to translate complex text into easily readable material. Was Used As An Instructional Strategy? Maybe you have some of these key skills . Maybe your skill set is completely different. We’ve put together examples for cheap essay help you ( see below ) to help you brainstorm so you don’t leave out any of your best skills for a resume.

Next, match your list to the resume skills listed in the job description. All of the critical thinking was used as an instructional, personal skills and talents you have can fall into one of three categories: Transferable Skills - the definition of transferable skills are key skills that you can take with you from one job to another. Examples: Microsoft Excel or Phone Etiquette Job-related Skills - job-related skills are the specific skills you need to do a certain job. Examples: Scuba Diving or Java Programing Adaptive Skills - adaptive skills are personal attributes or skills you use to the crucible essays abigail survive life. Examples: Persuasion or Confidence. Why is this important? Because there are different ways to put work-related skills on your resume depending on which category they fall under. Step 1: Go through the job description to find the was used instructional strategy, job-related skills that are required for the position. Step 2: You should have most of these key skills. Otherwise, you won’t be able to do the ap essay hamlet, job. For this job, you need to be able to: Conduct webinars.

Attend informal dinner meetings. Speak in front of large groups. Discuss and present software. Step 3: These job-related skills should go in your resume skills section and possibly in instructional, your resume objective or summary so an online employer will see them right away. There should be evidence (work experience, education, training) that prove your ability to demonstrate these key skills on a resume . Pro Tip : You can also put these skills in thinking was used instructional strategy, bold , for example, conduct webinars . Using bold for keywords helps the draw the recruiter's eye while they are scanning, and will make you more memorable as well. Step 4: Next, look for all of the adaptive and transferable skills that the law homework help, employer wants on top of the regular job-related skills. Step 5: Sprinkle proof that you have these types of skills throughout your resume. Add a few with quantifiable proof to your professional skills list. Adaptive Skills for a Resume. Transferable Skills for a Resume.

2. Research People Who Already Have the Job You Want. Once you’ve mined the thinking, job description for examples of physical essay professional skills to include on your resume, visit LinkedIn for a little bit of snooping. Why do you want to peep on critical was used instructional strategy, other professionals? Researching other professionals' strengths will let you know what skills and abilities are already valued in help, that profession. Add any duplicates of your skills to your resume skills section. Pro Tip : For future reference, you can also check out the courses, certificates, education, and skills sections to critical thinking was used as an strategy unlock new achievements.

Now you know how to take your career to the next level with a similar course or training. 3. What Skills to the crucible essays about abigail Put on a Resume for Extra Value. Thinking As An Instructional Strategy? Now ask yourself: Are any of your transferable skills and qualifications missing? Remember transferable skills are the universal skills that translate across jobs - like being proficient in Excel or Spanish. Good skills like Excel and the crucible essays about abigail, Spanish are always relevant. If you missed any, add them even if they were not mentioned in the job description. 4. Add the Universal Skills That All Employers Want.

I know I’m getting repetitive: Go back and check one more time to make sure you have EVERYTHING. Remember, most of the unique skills that you put on your resume should be job-related skills taken from the critical thinking as an instructional, job description and your best transferable skills. Adding a couple of your best universally desired skills is a way of sweetening the deal, but don't overdo it or base your entire resume on these examples of a comparison and contrast essay on high school and college skills. Have a look at our resume skills list. Do you have any of them?

5. Numbers and Facts Will Make You Stand Out From the Crowd. Now, you're probably wondering how to put skills on a resume to convince the recruiter you’re the critical thinking instructional strategy, best fit? Use facts and and contrast essay on high and college, figures. Thinking Was Used Instructional? Forget about superfluous adjectives. It’s as simple as that. Use proof to persuade to draw recruiter’s attention. 6. And Contrast Essay School And College? Beat the Bots By Adding Keyword Skills. Today, a lot of resumes are read by robots before they ever fall into human hands. That’s right. You worked hard on your resume, but a lot of hiring managers won’t even bother to look at critical as an strategy it before having R2-D2 run a scan on it.

The software sorts through applicants’ resumes and compares the resume skills you’ve listed to those found in the job description. To pass the inspection, you have to match a certain amount of these keywords. You can visit Jobscan to see how well you've matched your resume to the job post. Around 70-80% of the a comparison essay and college, skills on critical was used as an instructional, your resume need to match the job description. Note, the percentage can differ depending on individual Human Resource departments. Law Homework Online? But, you can’t just pack your resume full of keyword skills to critical was used trick the bots. TheLadders say that Applicant Tracking Systems (ATS) are now able to contextualize the content of your resume. What does this mean?

The software can read your resume almost like a human. That doesn’t mean that keywords aren’t important. Keyword skills should appear throughout your resume. You just have to beauty definition make sure that skill sets are added in as an, a way that reflects your full experience learning, using, and working with those key skills. Cheap Essay Help? Pro Tip: You should label your resume skills section “Skills” so that any ATS program can easily identify it. Want more tips? Read our complete guide: 42 Amazing Resume Tips That You Can Use In 30 Minutes [Examples] The Technical Skills That Employers Desire the Most. The shift to a technology-based economy has made science, engineering, math, and IT skills some of the most in-demand skills for a resume among employers. So, what are the best technical skills for a resume?

LinkedIn made a list of the 25 top hard skills for a resume in 2016 , and it’s all tech skills. The number one skill was “Cloud and Distributed Computing.” Technical skills are either something you have or you don’t, but they are always something that you can learn. Most people will only be required to critical thinking was used have basic technical skills on their resumes like software skills - e.g., the ability to use Microsoft Office and Excel. Professional skills on a resume are the one thing that will quickly communicate to an employer that you are the right fit for a job. And after you’ve proven that, the fact that you have listed universally desirable skills on walk essay, your resume will put you ahead of the pack.

That’s why it is critical was used instructional, important to: Carefully craft a good skills section for your resume. Place key skills throughout your resume. And now you know how! INFOGRAPHIC - Everything You Need To Know About Your Resume's Skill Section. Morning? The infographic featured below will show you the critical thinking was used as an, most desirable skills to essay put on a resume and critical was used strategy, how to showcase them. Like the infographic? Feel free to share it or use it on your site. I'll be happy to write a personalized introduction for your blog.

What skills should you put on help, a resume to get an upper hand? Leave a comment if you have any questions about what skills to was used as an instructional put on a resume or how to add them. Natalie is definition essay, a writer at Uptowork. Thinking Instructional? She loves writing about resumes and eating tacos more than life itself. Cheap Essay Help? She spends her free time reading complicated novels and binge watching TV series.

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Dissertations and Theses Authored by Counselor Eduation Alumni. Listed below are theses and dissertations dating back to 1964. For instructions on locating theses and dissertations published by thinking instructional, students in the Counselor Education Program, please link to http://www.uflib.ufl.edu/jgs/diss.html. To locate a specific publication, please link to the University of ap essay Florida libraries at http://www.uflib.ufl.edu/. Cheung, C. Critical Was Used As An Instructional Strategy! (2017). East meets west: Developing a bicultural identity in east Asian American youth . (Doctoral dissertation).

University of Florida, Gainesville, Florida. Fields, K. G. (2017). A phenomenological look at adoptive nesting to prepare for morning walk small, adoptive motherhood . (Doctoral dissertation). University of Florida, Gainesville, Florida. Fields, K. M. (2017). Examining the relationships among neighborhood, family, and individual child characteristics and critical thinking was used instructional strategy adverse childhood experiences. University of Florida, Gainesville, Florida. Neely, J. (2017).

Couples therapy to definition, improve the marriage for parents with a child with autism . Critical Thinking Was Used Instructional Strategy! University of essay help Florida, Gainesville, Florida. Anthony, C, Jr. Critical Thinking Was Used As An Instructional! (2016). Black college student-athlete identity achievement status: An intersection of racial identity, athletic identity, and gender . (Doctoral dissertation). University of Florida, Gainesville, Florida. Burtzlaff, P. (2016). Clergy premarital counseling with lower socioeconomic couples . (Doctoral dissertation). University of Florida, Gainesville, Florida. Dyce, C. (2016). Investigating pediatric mental health care access and parent satisfaction in the patient-centered medical home . (Doctoral dissertation).

University of Florida, Gainesville, Florida. Jaramillo, A. (2016). Counselor education trainees comfort and willingness to discuss sexuality issues with clients . (Doctoral dissertation). University of Florida, Gainesville, Florida. Johnson, J. (2016). Physical Essay! Looking back: The experiences of unauthorized Mexican individuals with their high school counselors . University of critical thinking was used as an instructional strategy Florida, Gainesville, Florida. Logan, S. (2016). Examining psychological hardiness and leadership practices and their relation to occupational satisfaction among counselor educators . University of Florida, Gainesville, Florida. Studer-Brynes, E. (2016). Refining tools for practitioners: A psychometric evaluation of the Career Search Self-Efficacy Scale using item response theory methodology. University of Florida, Gainesville, Florida.

Wargovich, B. (2016). Attachment, differentiation, and God attachment: Three views of the togetherness and separateness conundrum . University of Florida, Gainesville, Florida. Allen, C. (2015). A grounded theory study of counselors’ theoretical orientation development using narrative pedagogy . (Doctoral dissertation). University of Florida, Gainesville, Florida. Chen, P. (2015). Development and initial validation of the Multicultural Counseling Self Efficacy Scale for counselors in Taiwan . (Doctoral dissertation).

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Keith, Edwin Monroe, 1948- The work values and career maturity of community college transfer and native students / by Edwin Monroe Keith, Jr. Critical As An Instructional Strategy! 1976. Maurer, Carolyn Gwen, 1945- The effects of a self-instruction program in facilitation and communication skills for elementary school teachers / by cheap help, Carolyn Gwen Maurer. 1976. Mullin, Patrick Gerard, 1934- The effects of a Pre Cana Conference : a Catholic premarriage education experience / by Patrick Gerard Mullin. 1976.

Page, Richard Collin, 1943- Marathon group counseling with imprisoned female drug abusers / by Richard Collin Page. 1976. Pyle, K. Critical Was Used As An Instructional! Richard, 1939- The relationship of group career counseling and computer-assisted career guidance to the career maturity of community college students / by K. Richard Pyle. 1976. Thompson, Garth Dewayne, 1925- A theory of counseling for development of moral character / by Garth Dewayne Thompson. 1976. Voss, Phyllis MacKenzie Gierlotka. The long-term effects of a drop-out prevention program for junior and senior high school students / by Phyllis MacKenzie Gierlotka Voss. Physical Beauty Definition Essay! 1976.

Wilkinson, Gary Scott, 1946- Small group counseling with elementary school children of divorce / by Gary S. Wilkinson. 1976. Anderson, Ronald Francis, 1945- Using guided fantasy and modeling to modify the acting-out behavior of fifth grade boys / by Ronald Francis Anderson. 1975. Cross, Ellen Gail, 1945- The effects of a vocational exploration group program with middle and high school students / by Ellen Gail Cross. 1975. Davis, John Mathew, 1940- Student affairs at the University of critical thinking was used as an Florida as perceived by black, Cuban and white students of both sexes / by John Mathew Davis. 1975. Deitz, George Lee, 1942- Paraprofessional helper candidates’ perceptual organization and their level of interpersonal functioning / by George Lee Deitz. 1975. Devine, Howard Francis, 1945- The effects of a computer-based career counseling program on the vocational maturity of essays community college students / by Howard Francis Devine.

1975. Gumaer, Jim. Thinking Was Used Instructional Strategy! Peer-facilitator training and group leadership experiences with low-performing elementary school students / by cheap, D. Critical Thinking Was Used Strategy! James Gumaer. 1975. Horn, Mary Lemkau, 1940- The integration of negative experience by high and low functioning women / by Mary Lemkau Horn. 1975. Jonassen, Ellen Osterbind, 1949- Directions for the future of student personnel services in Florida’s community colleges / by Ellen Osterbind Jonassen. 1975. Korb, Margaret Patton, 1920- Changes in perceptual field characteristics of students in Gestalt-oriented training / by Margaret Patton Korb. 1975.

Landsman, Mary Elizabeth Baggett, 1933- Community college reading programs : staff and functions / by Mary Elizabeth Baggett Landsman. 1975. Lanier, James Edward, 1942- Teachers’ attitudes toward students’ race, socio-economic status, sex, and classroom behavior on their referral to an educable mentally retarded program (EMR) / by James Edward Lanier. 1975. Mercer, Roy Calvin, 1934- Methodological problems in morning small, tape rating of client process levels: the influence of therapist statements on rater judgments of client self-exploration Roy Calvin Mercer, Jr. 1975.

Newman, Laura Eager, 1928- Counselor characteristics and training as related to the process of critical was used instructional empathy and its manifestations / by Laura Eager Newman. 1975. Parker, Woodrow McClain, 1941- The effectiveness of a race relations communications program with blakc and white fraternity pledges, by Woodrow McCain Parker. 1975. Piercy, Fred Penrose, 1947- The relationships among student counselors’ self-ratings, peer ratings, supervisor ratings, and client ratings of counselor effectiveness / by Fred P. Piercy.

1975. Radtke, David Michael. Help! The effects of a tri-informant feedback system on thinking was used instructional strategy client goal attainment / by David Michael Radtke. Hamlet! 1975. Russell, Timothy Joseph, 1943- Selected factors that influence decisions among university students to seek marriage counseling / by Timothy Joseph Russell. 1975. Scouller, John Deans, 1939- Guidance needs of middle school educable mentally retarded and gifted children / by John Deans Scouller III. Critical As An Strategy! 1975. Swanson, John LeRoy, 1945- The relationship between perceptual characteristics and counselor effectiveness ratings of counselor trainees, by John LeRoy. Physical Definition Essay! 1975. Smith, Annie Delories, 1944- The impact of desegregation on was used the Florida Statewide Twelfth Grade Achievement Test scores of black and white students in a rural and an urban Florida county / by Annie Delories Smith.

1975. Spisso, Nancy Ann Slicner, 1947- The relationship of counselor’s visual and auditory discrimination abilities and perceived client satisfaction / by Nancy Ann Slicner Spisso. 1975. Weikel, William Joseph, 1949- Differentiating characteristics of autoevolutionary and modal persons / by William Joseph Weikel. 1975. Yates, Philip Randolph, 1946- The relationship between self-concept and academic achievement among gifted elementary school students, by Philip Randolph Yates. 1975. Jones, Elizabeth Lovelace, 1922- A comparison of help problems urban black and white high school pupils are willing to discuss with a counselor. 1974. Millott, Robert Frederick, 1935- Reading performance as a correlate of the personality type of college freshmen, by Robert F. Millott. 1974.

North, Robert William, 1940- A comparison of in-service training programs for social work aides. 1974. Orlando, Jacqueline Zurcher-Brower, 1937- Learned self-regulation and thinking as an arterial hypertension utilizing biofeedback and relaxation training. 1974. Stebbins, Linda Barton, 1942- Stress and satisfaction in graduate students’ marriages. 1974. Thigpen, Joe Dennard, 1942- Most and least helpful experiences in the supervision of beauty definition essay paraprofessional mental health workers. 1974. Yates, Lauren Elaine Lucas, 1949- A comparison of the effects of individual nondirective play therapy and structured teacher guidance upon second grade students of low sociometric status : an experimetnal study, by Lauren E. Lucas Yates. 1974. Bailey, Sara Joy, 1938- Effects of a classroom simulation on selected career decision-making variables with ninth-grade students.

1973. Eisele, John Howard, 1932- A survey of the critical as an strategy reported probable behavior of school counselors regarding the disclosure of confidential information. 1973. Hasterok, Judith Ban, 1930- A procedure for and the effects of the crucible essays about abigail becoming aware of anger by Judith B. Hasterok. 1973.

Smith, Stella Mae, 1945- Intense experiences of critical thinking instructional strategy black and white female prisoners. 1973. Wehr, Marcia, 1946- A study of the relationship between group facilitative involvement and predicted effectiveness of counselor paraprofessionals. 1973. Davis, Jannar William, 1944- Behavior charting as an adjunct to the dyadic counseling relationship. 1972. Haight, Donald Alexander, 1946- Video tape feedback in group encounter with community college students. 1972.

Hammond, Ralph Bert, 1943- Similarity, role, and setting as determinants of attraction by Ralph B. A Comparison And Contrast School And College! Hammond. 1972. Hilliard, Ted Richard, 1933- Rehabilitation counselor personal characteristic type realtionship to thinking was used as an instructional, counselor performanmce ratings Ted R. Hilliard. 1972. Landau, Marcia Goodman, 1940- Comparisons of the perceptions of social interactions of clinic and non-clinic children. 1972. Lennon, William James, 1940- A study of the effects of counseling practicum supervisor offered facilitative conditions on supervisee self-exploration. 1972. Persons, William Ernest, 1942- Occupational prediction as a function of the counselor’s racial and sexual bias. 1972.

Resnick, Jaquelyn Liss, 1946- The effectiveness of a brief communications skills program involving facilitative responding and self-disclosure training for student volunteers in college residence halls. 1972. Sitzman, Michael Jay, 1937- The prediction of academic success for transfer students from Florida public community colleges to essays about abigail, the University of Florida. 1972. Stormer, Jane Elizabeth Yaple, 1941- Critical factors of more helping and less helping behavior of as an instructional strategy paraprofessionals in the residence hall setting. Cheap Essay! 1972. Stormer, Jay Rockey, 1941- Drug use and attitudes toward drugs of college freshmen and their parents. 1972. Dowling, Jean Boyd, 1923- An evaluative analysis of the year-long work. 1971.

Forsythe, Jack Norman, 1931- Student and counselor perception of counselor functions in Tennessee community colleges. 1971. McCarty, Philip Thomas, 1942- Effects of sub-professional group counseling with probationers and parolees. 1971. Penry, Irene Frees, 1939- Conceptual systems and self-exploration.

1971. Sales, Amos Paul, 1941- Rehabilitation counselor candidate change resulting from sensitivity group experiences. 1971. Swander, Karen Keck, 1943- An analogue study of the effects of therapists’ level of functioning on co-therapists’ level of functioning and critical thinking was used as an strategy activity level within a multiple therapy situation. 1971. Bosbyshell, William Allen, 1933- Some correlates of empathic counseling behavior of Episcopal clergymen. 1970. Duncan, Clarence Wallace, 1934- A comparison of certain experiences by life stages of selected groups of self-actualzied, modal, and low-functioning college students.

1970. Herman, Susan Jane, 1939- The relationship between maternal variable scores and infant performance in a Negro experimental stimulation training population. 1970. Kelly, Francis Donald 1943- The differential effects of giving versus receiving help in a cross-age helping program. 1970. Koger, Mildred Nichols, 1928- Best teacher-student interpersonal relationships : their relationship to self-esteem and the frequency of the dialogical relation among music teachers. 1970.

Neil, Thomas Cleveland, 1939- Criminal offender preference for counselor background and counseling technique. 1970. Northrop, James Clement, 1930- Verbal interview behavior of a selected group of experienced, practicing counselors. 1970. Pare, Donald David, 1928- Accurate Empathy Scale : relative or absolute? 1970. Rice, Ronald Gene, 1941- A scale for measuring attitude changes among inmates of essays about local jails and among correctional workers. 1970. Rothman, Leslie Kenneth, 1938- The personal theory of the counselor : some biographical and psychometric correlates of selection of a theory of personality and a method of counseling by selected counselors. 1970. Rowe, Eleanor Belle Callon, 1936- Humanistic dimensions in academic achievement.

1970. Lee, Robert Edward, 1927- Some effects of a protestant clergy stereotype on counselor preference, self-disclosure readiness, and critical was used as an instructional strategy desire for cheap help, counseling among junior college students. 1969. Martin, Donald Glendinning, 1941- A method of self-evaluation for counselor education. 1968. Brady, Kathleen Faye, 1920- College application procedures as they influence efficient use of high school counselor time. 1967.

Schoch, Eugene Walter, 1927- The effect of a summer counselor education experience on in-service counselors’ concepts of and thinking instructional behavior in the counseling relationship. 1965. Bedingfield, James Walter, 1922- A study of the effectiveness of counselor-teacher consultation in aiding students in personal and school adjustment. 1964. Updated September 30, 2017.

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essays criminology Criminological researchers – coming from a variety of disciplines – draw from research techniques used in sociology, psychology, political science and critical was used as an strategy history, to name just a few. In recent years, though, criminologists too have become more reflective about research issues affecting their own subject relative to others, resulting in a number of specialist texts (Jupp, 1989; Maxfield and Babbie, 1995; Sapsford, 1996; Jupp et al. 2000; King and Wincup, 2000; Champion, 2000). Definition? A question that students, teachers and researchers in criminology often grapple with is whether there is anything distinctive about criminological research compared with research in was used strategy, other disciplines in the human and social sciences. Up until the 1970s, the study of crime and deviance was very much a male province.

British sociologist Carol Smart in her book Women, Crime and Criminology, published in 1977, documented the neglect of women in such study. She also showed that when women had been included, the and contrast and college approach had usually been highly sexist or outrightly misogynist. Was Used Instructional Strategy? The contributions of feminist scholars to the study of crime raised some fundamental questions. One question is what Kathy Daly and Meda Chesney Lind (1988) have called ‘the generalisability problem’. Ap Essay Questions Hamlet? This refers to whether theories generated to explain male offending can be used to explain female offending. Can women simply be inserted into critical was used, theories that explain male offending, or are new theoretical developments necessary to explain female crime? In redressing the omissions of criminology, feminist scholars saw an additional – but also an cheap essay, obvious – neglect of a focus upon critical thinking was used, men as men. Although crime is indeed largely – although not exclusively – committed by physical beauty definition men, this dimension of analysis had been largely ignored: it was a key missing link. Hence, feminist criminologists began to raise the issue of masculinity and crime. Critical? They have suggested that since more men are involved in crimes, there may be a link between forms of masculinity and forms of crime.

It is only relatively recently, then, that the obvious fact that crime is in some way bound up with masculinity has been taken up as in any way problematic. Much of the subsequent relevant research to help date has tended to concentrate on was used strategy the two areas of domestic violence and youth crime. In Britain, as well in North America, some minority ethnic groups, and morning especially black communities, are over-represented in the criminal justice process – in police stops, in appearances in court, and in the prison population. Many commentators give the impression – especially in elements of the critical was used as an strategy popular press – that some minority ethnic communities are somehow more criminally inclined than others. Such an impression both reflects and cheap essay help reinforces racist ideologies. Various factors are at work that account for crime. Crime is not evenly distributed across the social spectrum, and age, location, gender and socio-economic position are important variables in accounting for offending and victimization. Analysing the relationship between ‘race’ and crime seriously also means taking account of critical as an strategy, discrimination in the criminal justice system. In Britain, the racist murder of black teenager Stephen Lawrence by a gang of white youths at a bus stop in London in 1993 – and questions the inquiry into the police investigation that followed – thrust the was used instructional strategy tragedy of violent racism into the public consciousness with a potency never present before. The flawed police investigation into physical beauty essay, the murder became, for many, symbolic of the character of was used strategy, relations between the police and minority ethnic communities in Britain. Fundamentally, using the ap essay questions language of 1960s Black Power activists in the United States, the ‘Macpherson Inquiry’ (1999) observed that the police investigation was characterised by institutional racism.

Prior to the investigation, researchers had been producing evidence of racial prejudice and discrimination among some police officers for over two decades. The main source of was used as an instructional, official recorded crime statistics for Britain is the online annual publication Criminal Statistics, which has separate volumes for England and Wales, Scotland, and Northern Ireland. Data are published on the Internet and so are readily accessible for students, the critical thinking was used as an strategy general public, journalists, and anybody else with an interest. The crimes recorded by cheap essay help no means reflect the full extent of unlawful activity. To take the case of England and Wales, there are a number of omissions in terms of the scope of their coverage. The figures do not include data from police forces for which the Home Office is not responsible – for instance, the British Transport Police, Ministry of Defence Police, and the UK Atomic Energy Police, who publish their own statistics. Nor do they include cases of tax and benefit fraud known to agencies such as the Inland Revenue, Customs and Excise, and critical thinking was used strategy the Department of Social Security, which have their own investigative and morning walk prosecutional functions. One type of crime, racist crime – crimes in which victims are targeted because of their ‘race’ or ethnicity – provides a very useful exemplar to illustrate some of the limitations of recorded crime data.

Data on racist incidents for England and Wales can be found in Statistics on was used as an instructional strategy Race and the Criminal Justice System, published by the crucible essays the Home Office, the ministry responsible for crime and policing policy, immigration and nationality. Britain has a long history of racist crime (Bowling, 1998; Witte, 1996), but in instructional, statistical terms it simply did not exist before 1979, as it was not recorded in official statistics until then. In taking a critical view of the about number of instructional strategy, recorded racial incidents, the apparent increase over time could quite conceivably reflect changes in police recording practices and also perhaps a greater motivation by victims to report crimes. The sharp rise in the number of recorded incidents in the late 1990s following the publication of the report of the a comparison and contrast on high school and college Stephen Lawrence inquiry in 1999 (Macpherson, 1999) supports such an observation. Given the well-known limitations to police recorded crime statistics, many countries have established official crime victimization surveys. Critical Was Used Instructional Strategy? They attempt to shed light on the ‘dark figure’ of crime by law homework online asking samples of people directly about their experiences of crime victimization. In the United States, the National Crime Victimization Survey was established in 1972 and is now conducted annually.

The first national crime victimization survey in Britain, the British Crime Survey (BCS), was carried out in 1982, with further surveys in thinking instructional strategy, 1984, 1988, 1992, 1996 and 1998. In the 2000 British Crime Survey, close to 23,000 people aged 16 and over were interviewed. From 2001 the BCS moved to an annual cycle, with 40,000 respondents to cheap essay help be interviewed per year. The BCS measures the critical was used as an instructional amount of crime in England and walk essay Wales by critical was used as an instructional asking people about crimes they have experienced in the past year. It asks about people’s attitudes to crime, such as how much they fear crime and what measures they take to avoid it. Essays? It also asks about people’s attitudes to the criminal justice system, including the police and the courts. The survey findings are published in a variety of specialist reports available online on thinking as an the Home Office Website, and complete datasets of primary data are available for secondary analysis and can be obtained from the University of Essex data archive. Most interestingly, while the physical essay police statistics show a sharp increase in the number of racist incidents in the 1990s, a comparison of the estimates for the 1995 and 1999 British Crime Surveys actually shows a decline, suggesting that the thinking was used increase in recorded racial incidents recorded by the police is a combination of the increased willingness by victims to report them and improved police recording practices (Clancy et al., 2001). The critical perspective applied to official crime statistics to this point perhaps suggests that the morning walk small statistics provide more of an insight into official definitions of crime, crime recording and policing practice than into the actual level of unlawful activity. Thinking critically about crime statistics, though, also involves thinking about the potential they offer.

While the statistics may not provide the reliable measures of crime that policymakers, academics and journalists, for instance, would wish for, at the local level crime data collected by police forces and not routinely published provide a sound basis for evidence-based policing. A major aim behind the recording of thinking was used, all incidents reported to the police – even if some may not be subsequently classified as a crime – as set down by the national crime reporting standard introduced in 2002, is to provide more accurate intelligence for policing at the local level, and for intervention by and contrast school other agencies. While the limitations of official crime statistics frustrate criminologists, the potential of was used strategy, researching criminal activity first-hand has excited the criminological imagination. When researchers study those who engage in criminal activity they face, in the words of Soloway and Walters, ‘a true moral, ethical, and legal existential crisis’ (1977:161). One dilemma is whether researchers themselves should engage in criminal activity. Small Essay? Taken to its extreme, the logic of the ethnographic study of critical as an, criminality suggests that they should. Jeff Ferrell, one advocate of researchers crossing the line into physical definition, certain areas of criminality, argues that ‘For the thinking was used as an strategy dedicated field researcher who seeks to explore criminal subcultures and criminal dynamics, obeying the law may present as much of a problem as breaking it’ (1998:26).

Modernity brought many changes, and morning the criminological challenge of the twentieth century was to sift through these changes to ‘solve’ the crime problem. Before criminology did not really work very well. Indeed, the as an more that people studied crime, the more crime seemed to grow! Although there has been much theorising about crime, many criminology books written and many courses taught, we seem to be no nearer to solving the cheap help problem of crime. Criminology as we once knew it may well have failed. In the twenty-first century, this modern world is an accelerating one in which there is an increased sensitivity to thinking was used as an instructional strategy diversities and differences.

In this view, the world becomes less dominated by generalities and ‘master narratives’, and there is a turn towards ‘local cultures’ and their ‘multiplicity of stories’. Postmodernists argue for respecting the existence of a plurality of the crucible essays about, perspectives, as against a notion that there is one single truth from a privileged perspective; local, contextual studies in place of grand narratives; an emphasis on disorder, flux and openness, as opposed to critical was used strategy order, continuity and restraint. (Foucault 1996:22) An example of how crime is help, changing under conditions of critical thinking as an instructional strategy, late modernity can be found in law homework online, the recent work of Jock Young in his book The Exclusive Society (1999). In this he explores three kinds of critical thinking as an, division: economic (where people are excluded from the cheap essay labour market), social (where people are excluded from civil society) and the expansion of a criminal justice system (which excludes more and more people from daily life). Young sees crime as the defining feature of critical thinking, modern societies – it is ap essay, everywhere. True, there is a central core that is ordered and embedded, becoming an almost Disney-like ‘squeaky-clean’ world. But a cordon sanitaire encircles it, and we find whole groups subject to the new geographies of exclusion. He suggests that in all this, crime has moved from the rare, the abnormal, the offence of the marginal and the stranger, to a commonplace part of the texture of everyday life: it occupies the family, heartland of liberal democratic society as well as extending its anxiety into all areas of the city.

It is revealed in was used as an, the highest echelons of our economy and politics as well as in the urban impasses of the underclass. For Henry and Milovanovic (1996:116), crime is defined as ‘the power to deny others their ability to make a difference’. For example, crime as ‘harm’ occurs when people have their property stolen from them or their dignity stripped from them, or when they are prevented from achieving a desired goal because of sexism, racism or ageism. Crime then becomes domination, whether by single individuals (e.g. robbers), collectives (e.g. Ap Essay Hamlet? organised criminals or corporations), or by thinking state governments (as in ap essay, genocide, for example). Furthermore, crime is the ‘co-produced’ outcome not only of humans and their environments, but also of human agents and the wider society through its excessive investment in crime – through crime prevention, criminal justice agencies, criminal lawyers, criminologists, crime news, crime shows, crime books, and thinking was used as an strategy so on. 1. Bowling, B. (1998) Violent Racism: Victimization, Policing and Social Context, Oxford: Clarendon Press. 2. Definition? Champion, J. D. (2000) Research Methods for Criminal Justice and Criminology, Upper Saddle River, NJ: Prentice Hall. 3. Clancy, A., Hough, M., Aust, R. and Kershaw, C. Critical Thinking As An Instructional? (2001) Crime, Policing and essays abigail Justice: The Experience of thinking strategy, Ethnic Minorities, Findings from the 2000 British Crime Survey, Home Office Research Study 223, London: Home Office. 4. Daly, K. and walk small Chesney-Lind, M. (1988) ‘Feminism and Criminology’, Justice Quarterly, 5 (4): 498-538.

5. Ferrell, J. (1998) ‘Criminological Verstehen: Inside the Immediacy of Crime’, in J. Ferrell and M. Hamm (eds) Ethnography at the Edge: Crime, Deviance and Field Research, Boston: Northeastern University Press. 6. Henry, S. and critical Milovanovic, D. (1996) Constitutive Criminology: Beyond Postmodernism, London: Sage. 7. Jupp, V. (1989) Methods of Criminological Investigation, London: Allen and Unwin. 8. Jupp, V., Davies, P. and Francis, P. Ap Essay Questions? (eds.) (2000) Doing Criminological Research, London: Sage. 9. King, R. D. and Wincup, E. (eds) (2000) Doing Research on Crime and Justice, Oxford: Oxford University Press. 10.

Maxfield, M. G. and Babbie, E. Thinking Was Used As An? (1995) Research Methods for Criminal Justice and Criminology, Belmont, CA: Wadsworth. 11. Sapsford, R. (1996) Researching Crime and Criminal Justice, Milton Keynes: Open University Press. 12. Smart, C. (1997) Women, Crime and Criminology: A Feminist Critique, London: Routledge. 13. Soloway, I. and Walters, J. (1977) ‘Workin’ the Corner: The Ethics and Legality of Ethnographic Fieldwork among Active Heroin Addicts’, in R. S. Help? Weppner (ed.) Street Ethnography: Selected Studies of Crime and critical was used as an instructional strategy Drug Use in essay, Natural Settings, Beverly Hills, CA: Sage.

14. Thinking Was Used? Witte, R. (1996) Racist Violence and the State, Harlow: Longman. 15. Young, J. (1999a) The Exclusive Society, London: Sage. CustomEssayPapers.com is a provider of high quality, custom writing services and can write any kind of paper, including case studies. CustomEssayPapers.com is experienced in writing informative, detailed, and concise case studies on any subject and using either kind of case study approaches. If you need help with a case study, place your order for a case study and one of our professional writers will happily construct a case study for you or help you with any other writing assignment you may have: Essay , Research Paper , Thesis , Term Paper , etc.

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